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Autistic traits below the clinical threshold: re-examining the broader autism phenotype in the 21st century

Sucksmith, E.; Roth, I. and Hoekstra, R. A. (2011). Autistic traits below the clinical threshold: re-examining the broader autism phenotype in the 21st century. Neuropsychology Review, 21(4) pp. 360–389.

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Diagnosis, intervention and support for people with autism can be assisted by research into the aetiology of the condition. Twin and family studies indicate that autism spectrum conditions are highly heritable; genetic relatives of people with autism often show milder expression of traits characteristic for autism, referred to as the Broader Autism Phenotype (BAP). In the past decade, advances in the biological and behavioural sciences have facilitated a more thorough examination of the BAP from multiple levels of analysis. Here, the candidate phenotypic traits delineating the BAP are summarised, including key findings from neuroimaging studies examining the neural substrates of the BAP. We conclude by reviewing the value of further research into the BAP, with an emphasis on deriving heritable endophenotypes which will reliably index autism susceptibility and offer neurodevelopmental mechanisms that bridge the gap between genes and a clinical autism diagnosis.

Item Type: Article
Copyright Holders: 2011 Springer Science+Business Media, LLC
ISSN: 1573-6660
Keywords: autism; broader autism phenotype; social cognition; phenotypic heterogeneity; endophenotypes
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 29858
Depositing User: Rosa Hoekstra
Date Deposited: 20 Oct 2011 15:11
Last Modified: 16 May 2017 10:11
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