Schmidt, Mathias V.; Schülke, Jan-Philip; Liebl, Claudia; Stiess, Michael; Avrabos, Charilaos; Bock, Jörg; Wochnik, Gabriela M.; Davies, Heather A.; Zimmermann, Nicole; Scharf, Sebastian H.; Trümbach, Dietrich; Wurst, Wolfgang; Zieglgänsberger, Walter; Turck, Christoph; Holsboer, Florian; Stewart, Michael G.; Bradke, Frank; Eder, Matthias; Müller, Marianne B. and Rein, Theo
(2011).
| DOI (Digital Object Identifier) Link: | http://dx.doi.org/doi:10.1073/pnas.1103318108 |
|---|---|
| Google Scholar: | Look up in Google Scholar |
Abstract
Stress has been identified as a major causal factor for many mental disorders. However, our knowledge about the chain of molecular and cellular events translating stress experience into altered behavior is still rather scant. Here, we have characterized a murine ortholog of the putative tumor suppressor gene DRR1 as a unique stress-induced protein in brain. It binds to actin, promotes bundling and stabilization of actin filaments, and impacts on actin-dependent neurite outgrowth. Endogenous DRR1 localizes to some, but not all, synapses, with preference for the presynaptic region. Hippocampal virus-mediated enhancement of DRR1 expression reduced spine density, diminished the probability of synaptic glutamate release, and altered cognitive performance. DRR1 emerges as a protein to link stress with actin dynamics, which in addition is able to act on synaptic function and cognition.
| Item Type: | Journal Article |
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| Copyright Holders: | 2011 M. V. Schmidt |
| ISSN: | 1091-6490 |
| Funders: | EU FP7 Memstick |
| Keywords: | actin dynamics; stress physiology; stress regulation; synaptic plasticity; TU3A |
| Academic Unit/Department: | Science Science > Life, Health and Chemical Sciences |
| Item ID: | 29707 |
| Depositing User: | Michael Stewart |
| Date Deposited: | 07 Oct 2011 08:24 |
| Last Modified: | 16 Nov 2012 14:07 |
| URI: | http://oro.open.ac.uk/id/eprint/29707 |
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