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Michaluk, Piotr; Wawrzyniak, Marcin; Alot, Przemyslaw; Szczot, Marcin; Wyrembek, Paulina; Mercik, Katarzyna; Medvedev, Nikolay; Wilczek, Ewa; De Roo, Mathias; Zuschratter, Werner; Muller, Dominique; Wilczynski, Grzegorz M; Mozrzymas, Jerzy W; Stewart, Michael G.; Kaczmarek, Leszek and Wlodarczyk, Jakub
(2011).
DOI: https://doi.org/10.1242/jcs.090852
Abstract
An increasing body of data has shown that matrix metalloproteinase-9 (MMP-9), an extracellularly acting, Zn2+-dependent endopeptidase, is important not only for pathologies of the central nervous system but also for neuronal plasticity. Here, we use three independent experimental models to show that enzymatic activity of MMP-9 causes elongation and thinning of dendritic spines in the hippocampal neurons. These models are: a recently developed transgenic rat overexpressing autoactivating MMP-9, dissociated neuronal cultures, and organotypic neuronal cultures treated with recombinant autoactivating MMP-9. This dendritic effect is mediated by integrin β1 signalling. MMP-9 treatment also produces a change in the decay time of miniature synaptic currents; however, it does not change the abundance and localization of synaptic markers in dendritic protrusions. Our results, considered together with several recent studies, strongly imply that MMP-9 is functionally involved in synaptic remodelling.
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About
- Item ORO ID
- 29598
- Item Type
- Journal Item
- ISSN
- 1477-9137
- Project Funding Details
-
Funded Project Name Project ID Funding Body Not Set P-N/030/2006 The Polish Ministry of Science and Higher Education 7th FP EU grant Memstick Not Set European Union Not Set PNRF-96 Polish–Norwegian Research Fund Not Set Not Set Foundation for Polish Science Not Set Not Set European Molecular Biology Organization Not Set N401 541540 Polish Ministry for Science - Keywords
- brain; extracellular matrix; plasticity; proteases; MMP-9
- Academic Unit or School
-
Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM) - Copyright Holders
- © 2011. Published by The Company of Biologists Ltd
- Related URLs
- Depositing User
- Michael Stewart