Dorsal root ganglion neurons maintained in a 3D culture model exhibit similar electrophysiological properties to fresh explants

East, E.; Murphy, K. and Phillips, J. (2011). Dorsal root ganglion neurons maintained in a 3D culture model exhibit similar electrophysiological properties to fresh explants. In: Tissue and Cell Engineering Society, 19-21 Jul 2011, Leeds.

URL: http://www.ecmjournal.org/journal/supplements/vol0...

Abstract

Tissue engineered culture models provide a powerful tool for neuroscience research1. They overcome limitations associated with monolayer cultures of neurons and glia by maintaining cells in a more realistic 3D spatial arrangement, and permit continuous monitoring and control of variables that cannot be achieved in animal models. Here we report the development of a system for recording electrophysiological behaviour in neurons in 3D culture.

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