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Dorsal root ganglion neurons maintained in a 3D culture model exhibit similar electrophysiological properties to fresh explants

East, E.; Murphy, K. and Phillips, J. (2011). Dorsal root ganglion neurons maintained in a 3D culture model exhibit similar electrophysiological properties to fresh explants. In: Tissue and Cell Engineering Society, 19-21 July 2011, Leeds.

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Abstract

Tissue engineered culture models provide a powerful tool for neuroscience research1. They overcome limitations associated with monolayer cultures of neurons and glia by maintaining cells in a more realistic 3D spatial arrangement, and permit continuous monitoring and control of variables that cannot be achieved in animal models. Here we report the development of a system for recording electrophysiological behaviour in neurons in 3D culture.

Item Type: Conference Item
Copyright Holders: 2011 The Authors
ISSN: 1473-2262
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Science
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 29160
Depositing User: James Phillips
Date Deposited: 25 Jul 2011 10:51
Last Modified: 10 Mar 2014 15:32
URI: http://oro.open.ac.uk/id/eprint/29160
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