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NMR and UV studies of 4-Thio-2′-deoxyuridine and its derivatives

Zhang, Xiaohui and Xu, Yao-Zhong (2011). NMR and UV studies of 4-Thio-2′-deoxyuridine and its derivatives. Molecules, 16(7) pp. 5655–5664.

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DOI (Digital Object Identifier) Link: http://dx.doi.org/10.3390/molecules16075655
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Abstract

5-Substituted-4-thio-2’-deoxyuridine nucleosides have been chemically synthesized and studied by NMR and UV spectroscopy. The results have been analyzed and discussed in connection with the previous data. The imino proton signal and the carbon signal of the thiocarbonyl group in the 5-substituted-4-thio-2’-deoxyuridines were found to be at much lower field, offering a potential for monitoring these modified bases at the DNA level. All 4-thionucleosides have strong absorptions at around 340 nm and consequently would be useful as potential UVA-induced anticancer agents.

Item Type: Journal Article
Copyright Holders: 2011 The Authors
ISSN: 1420-3049
Project Funding Details:
Funded Project NameProject IDFunding Body
Not SetNot SetThe Open University, UK
Not SetNot Setthe Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry, China
Keywords: NMR; UV; 4-thiothymidine; DNA
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 29051
Depositing User: Yao Xu
Date Deposited: 07 Jul 2011 14:42
Last Modified: 11 Mar 2014 20:35
URI: http://oro.open.ac.uk/id/eprint/29051
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