Synthesis and biological evaluation of benzyl styrylsulfonyl derivatives as potent anticancer mitotic inhibitors.

Chahrour , Osama; Abdalla , Ashraf; Lam , Frankie; Midgley , Carol and Wang , Shudong (2011). Synthesis and biological evaluation of benzyl styrylsulfonyl derivatives as potent anticancer mitotic inhibitors. Bioorganic and Medicinal Chemistry Letters, 21(10) pp. 3066–3069.

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URL:	http://www.sciencedirect.com/science?_ob=ArticleUR...
DOI (Digital Object Identifier) Link:	http://dx.doi.org/doi:10.1016/j.bmcl.2011.03.041
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Abstract

We herein report the synthesis, biological activity and structure activity relationship of derivatives of benzylstyrylsulfone, benzylstyrylsulfine and benzylsulfonyl-N-phenylacetamide. A lead compound 7 represents a new class of mitotic inhibitors that demonstrates potent anti-proliferative activity and selectively induces cancer cell apoptosis while sparing non-transformed lung fibroblast.

Item Type:	Journal Article
Copyright Holders:	2011 Published by Elsevier Ltd.
ISSN:	0960-894X
Keywords:	mitotic inhibitor; polo-like kinase; serine/threonine kinase; anticancer therapy
Academic Unit/Department:	Science > Life, Health and Chemical Sciences
Item ID:	28576
Depositing User:	Carol Midgley
Date Deposited:	05 May 2011 08:24
Last Modified:	12 Apr 2013 01:55
URI:	http://oro.open.ac.uk/id/eprint/28576

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