Synthesis and biological evaluation of benzyl styrylsulfonyl derivatives as potent anticancer mitotic inhibitors

Chahrour, Osama; Abdalla, Ashraf; Lam, Frankie; Midgley, Carol and Wang, Shudong (2011). Synthesis and biological evaluation of benzyl styrylsulfonyl derivatives as potent anticancer mitotic inhibitors. Bioorganic and Medicinal Chemistry Letters, 21(10) pp. 3066–3069.

DOI: https://doi.org/10.1016/j.bmcl.2011.03.041

URL: http://www.sciencedirect.com/science?_ob=ArticleUR...

Abstract

We herein report the synthesis, biological activity and structure activity relationship of derivatives of benzylstyrylsulfone, benzylstyrylsulfine and benzylsulfonyl-N-phenylacetamide. A lead compound 7 represents a new class of mitotic inhibitors that demonstrates potent anti-proliferative activity and selectively induces cancer cell apoptosis while sparing non-transformed lung fibroblast.

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