Chahrour , Osama; Abdalla , Ashraf; Lam , Frankie; Midgley , Carol and Wang , Shudong
Synthesis and biological evaluation of benzyl styrylsulfonyl derivatives as potent anticancer mitotic inhibitors.
Bioorganic and Medicinal Chemistry Letters, 21(10) pp. 3066–3069.
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We herein report the synthesis, biological activity and structure activity relationship of derivatives of benzylstyrylsulfone, benzylstyrylsulfine and benzylsulfonyl-N-phenylacetamide. A lead compound 7 represents a new class of mitotic inhibitors that demonstrates potent anti-proliferative activity and selectively induces cancer cell apoptosis while sparing non-transformed lung fibroblast.
||2011 Published by Elsevier Ltd.
||mitotic inhibitor; polo-like kinase; serine/threonine kinase; anticancer therapy
||Science > Life, Health and Chemical Sciences
||05 May 2011 08:24
||12 Apr 2013 01:55
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