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Synthesis and biological evaluation of benzyl styrylsulfonyl derivatives as potent anticancer mitotic inhibitors

Chahrour, Osama; Abdalla, Ashraf; Lam, Frankie; Midgley, Carol and Wang, Shudong (2011). Synthesis and biological evaluation of benzyl styrylsulfonyl derivatives as potent anticancer mitotic inhibitors. Bioorganic and Medicinal Chemistry Letters, 21(10) pp. 3066–3069.

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URL: http://www.sciencedirect.com/science?_ob=ArticleUR...
DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1016/j.bmcl.2011.03.041
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Abstract

We herein report the synthesis, biological activity and structure activity relationship of derivatives of benzylstyrylsulfone, benzylstyrylsulfine and benzylsulfonyl-N-phenylacetamide. A lead compound 7 represents a new class of mitotic inhibitors that demonstrates potent anti-proliferative activity and selectively induces cancer cell apoptosis while sparing non-transformed lung fibroblast.

Item Type: Journal Article
Copyright Holders: 2011 Published by Elsevier Ltd.
ISSN: 0960-894X
Keywords: mitotic inhibitor; polo-like kinase; serine/threonine kinase; anticancer therapy
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 28576
Depositing User: Carol Midgley
Date Deposited: 05 May 2011 08:24
Last Modified: 09 Mar 2014 02:21
URI: http://oro.open.ac.uk/id/eprint/28576
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