The Open UniversitySkip to content
 

Paracrine relationships between adipose and lymphoid tissues: implications for the mechanism of HIV-associated adipose redistribution syndrome

Pond, Caroline M. (2003). Paracrine relationships between adipose and lymphoid tissues: implications for the mechanism of HIV-associated adipose redistribution syndrome. Trends in Immunology, 24(1) pp. 13–18.

DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1016/S1471-4906(02)00004-2
Google Scholar: Look up in Google Scholar

Abstract

Paracrine interactions between lymphoid cells and adipocytes surrounding lymph nodes improve the efficiency of immune responses by emancipating activated lymphoid cells from competition with other tissues for blood-borne nutrients. HIV infection may disrupt this relationship, causing lipodystrophy.
The adipocytes anatomically associated with lymph nodes and omental milky spots have site-specific properties that equip them to interact locally with lymphoid cells. Paracrine provisioning of peripheral immune responses improves their efficiency and emancipates activated lymphocytes from competition with other tissues for blood-borne nutrients. Prolonged disruption to such paracrine interactions may contribute to the HIV-associated adipose redistribution syndrome, causing selective hypertrophy of the mesentery, omentum and other adipose depots that contain much activated lymphoid tissue.

Item Type: Journal Article
ISSN: 1471-4906
Keywords: lymph nodes; perinodal adipose tissue; local interaction; cytokines; HARS; enertic efficiency; evolution of immune system
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 2852
Depositing User: Caroline Pond
Date Deposited: 19 Jun 2006
Last Modified: 10 Mar 2014 10:34
URI: http://oro.open.ac.uk/id/eprint/2852
Share this page:

Altmetrics

Scopus Citations

Actions (login may be required)

View Item
Report issue / request change

Policies | Disclaimer

© The Open University   + 44 (0)870 333 4340   general-enquiries@open.ac.uk