Pond, Caroline M.
|DOI (Digital Object Identifier) Link:||http://doi.org/10.1016/S1471-4906(02)00004-2|
|Google Scholar:||Look up in Google Scholar|
Paracrine interactions between lymphoid cells and adipocytes surrounding lymph nodes improve the efficiency of immune responses by emancipating activated lymphoid cells from competition with other tissues for blood-borne nutrients. HIV infection may disrupt this relationship, causing lipodystrophy.
The adipocytes anatomically associated with lymph nodes and omental milky spots have site-specific properties that equip them to interact locally with lymphoid cells. Paracrine provisioning of peripheral immune responses improves their efficiency and emancipates activated lymphocytes from competition with other tissues for blood-borne nutrients. Prolonged disruption to such paracrine interactions may contribute to the HIV-associated adipose redistribution syndrome, causing selective hypertrophy of the mesentery, omentum and other adipose depots that contain much activated lymphoid tissue.
|Item Type:||Journal Article|
|Keywords:||lymph nodes; perinodal adipose tissue; local interaction; cytokines; HARS; enertic efficiency; evolution of immune system|
|Academic Unit/Department:||Science > Life, Health and Chemical Sciences
|Interdisciplinary Research Centre:||Biomedical Research Network (BRN)|
|Depositing User:||Caroline Pond|
|Date Deposited:||19 Jun 2006|
|Last Modified:||14 Jan 2016 15:51|
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