Pond, C.M.; Mattacks, C.A and Sadler, D.
PDF (Not Set)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
|DOI (Digital Object Identifier) Link:||http://doi.org/10.1079/BJN20041147|
|Google Scholar:||Look up in Google Scholar|
The effects of dietary lipids on the abundance of dendritic cells in adipose tissue in anatomically defined relationships to chronically inflamed lymph nodes were investigated in mature male rats fed on plain chow or chow plus 20% sunflower or fish oil. The popliteal lymph nodes were stimulated by local subcutaneous injection of 20 µg lipopolysaccharide to both hindlegs three times/week for 2 weeks. The masses of the major adipose depots and the numbers of dendritic cells emerging from perinodal adipose tissue and samples 5 and 10 mm from popliteal lymph nodes were measured, and those from omental and mesenteric adipose tissue around and remote from lymphoid tissue, and mesenteric and popliteal lymph nodes. Dendritic cells were most numerous in the perinodal adipose tissue, with the corresponding 'remote' samples containing 25-50% fewer such cells under all conditions studied. Dietary sunflower oil increased the numbers of dendritic cells by about 17% in all adipose samples and fish oil reduced the numbers in perinodal tissue by about 5%. The fish-oil diet diminished responses of the intra-abdominal adipose depots to local stimulation of the popliteal node. Correlations in dendritic cell numbers were stronger between perinodal samples from different depots than between remote and perinodal samples from the same depot and after the sunflower-oil diet compared to fish oil.
These data show that dietary lipids modulate numbers of dendritic cells in lymphoid tissue-containing adipose depots and support the hypothesis that perinodal adipose tissue interacts locally with lymphoid cells.
|Item Type:||Journal Article|
|Keywords:||rat; popliteal; mesenteric; omental; local interactions; fish oil; sunflower oil; lymph nodes|
|Academic Unit/Department:||Science > Life, Health and Chemical Sciences
|Interdisciplinary Research Centre:||Biomedical Research Network (BRN)|
|Depositing User:||Caroline Pond|
|Date Deposited:||19 Jun 2006|
|Last Modified:||23 Feb 2016 18:30|
|Share this page:|
Download history for this item
These details should be considered as only a guide to the number of downloads performed manually. Algorithmic methods have been applied in an attempt to remove automated downloads from the displayed statistics but no guarantee can be made as to the accuracy of the figures.