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Tidcombe, Hester; Jackson-Fisher, Amy; Mathers, Kathleen; Stern, David F.; Gassmann, Martin and Golding, Jon P.
(2003).
DOI: https://doi.org/10.1073/pnas.1436402100
URL: http://www.pnas.org/cgi/content/full/100/14/8281
Abstract
Mice lacking the epidermal growth factor receptor family member ErbB4 exhibit defects in cranial neural crest cell migration but die by embryonic day 11 because of defective heart development. To examine later phenotypes, we rescued the heart defects in ErbB4 mutant mice by expressing ErbB4 under a cardiac-specific myosin promoter. Rescued ErbB4 mutant mice reach adulthood and are fertile. However, during pregnancy, mammary lobuloalveoli fail to differentiate correctly and lactation is defective. Rescued mice also display aberrant cranial nerve architecture and increased numbers of large interneurons within the cerebellum.
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About
- Item ORO ID
- 2774
- Item Type
- Journal Item
- ISSN
- 1091-6490
- Academic Unit or School
-
Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM) - Depositing User
- Jon Golding