The Open UniversitySkip to content
 

Neural and mammary gland defects in ErbB4 knockout mice genetically rescued from embryonic lethality

Tidcombe, Hester; Jackson-Fisher, Amy; Mathers, Kathleen; Stern, David F.; Gassmann, Martin and Golding, Jon P. (2003). Neural and mammary gland defects in ErbB4 knockout mice genetically rescued from embryonic lethality. Proceedings of the National Academy of Sciences of the United States of America, 100(14) pp. 8281–8286.

URL: http://www.pnas.org/cgi/content/full/100/14/8281
DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1073/pnas.1436402100
Google Scholar: Look up in Google Scholar

Abstract

Mice lacking the epidermal growth factor receptor family member ErbB4 exhibit defects in cranial neural crest cell migration but die by embryonic day 11 because of defective heart development. To examine later phenotypes, we rescued the heart defects in ErbB4 mutant mice by expressing ErbB4 under a cardiac-specific myosin promoter. Rescued ErbB4 mutant mice reach adulthood and are fertile. However, during pregnancy, mammary lobuloalveoli fail to differentiate correctly and lactation is defective. Rescued mice also display aberrant cranial nerve architecture and increased numbers of large interneurons within the cerebellum.

Item Type: Journal Article
ISSN: 1091-6490
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 2774
Depositing User: Jon Golding
Date Deposited: 16 Jun 2006
Last Modified: 07 Mar 2014 13:51
URI: http://oro.open.ac.uk/id/eprint/2774
Share this page:

Altmetrics

Scopus Citations

Actions (login may be required)

View Item
Report issue / request change

Policies | Disclaimer

© The Open University   + 44 (0)870 333 4340   general-enquiries@open.ac.uk