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Regulation of Fc receptor and major histocompatibility complex antigen expression on isolated rat microglia by tumour necrosis factor, interleukin-1 and lipopolysaccharide: effects on interferon-gamma induced activation

Loughlin, A. J.; Woodroofe, M. N. and Cuzner, M. L. (1992). Regulation of Fc receptor and major histocompatibility complex antigen expression on isolated rat microglia by tumour necrosis factor, interleukin-1 and lipopolysaccharide: effects on interferon-gamma induced activation. Immunology, 75(1) pp. 170–175.

URL: http://onlinelibrary.wiley.com/journal/10.1111/(IS...
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Abstract

Isolated rat brain microglia display enhanced expression of Fc receptors on treatment with interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1) and lipopolysaccharide (LPS), whereas major histocompatibility complex (MHC) antigen expression is enhanced only by IFN-gamma. Although TNF and LPS individually have no effect on MHC expression by microglia, they both antagonize IFN-gamma-induced expression. The enhanced expression of Fc receptors observed in the presence of IFN-gamma, TNF or LPS is significantly inhibited by the combination of IFN-gamma with either LPS or TNF. IL-1 alpha has little effect on IFN-gamma-induced MHC or Fc receptor expression by microglia. Peritoneal macrophages behave similarly to microglia, with the notable exception that IL-1 alpha enhances IFN-gamma-induced FcR expression. These observations suggest that the functional activity of microglia during inflammation or demyelination in the central nervous system can be influenced by the changing profile of cytokines present during lesion development.

Item Type: Journal Article
Copyright Holders: 1992 Blackwell Publishing Ltd
ISSN: 1365-2567
Project Funding Details:
Funded Project NameProject IDFunding Body
Not SetNot SetMultiple Sclerosis Society of Greal Britain
Not SetNot Setthe Brain Research Trust
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Related URLs:
Item ID: 27034
Depositing User: Jane Loughlin
Date Deposited: 20 Apr 2011 09:30
Last Modified: 07 Mar 2014 13:47
URI: http://oro.open.ac.uk/id/eprint/27034
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