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Microwave induced MIP synthesis: comparative analysis of thermal and microwave induced polymerisation of caffeine imprinted polymers

Turner, Nicholas W.; Holdsworth, Clovia I.; Donne, Scott W.; McCluskey, Adam and Bowyer, Michael C. (2010). Microwave induced MIP synthesis: comparative analysis of thermal and microwave induced polymerisation of caffeine imprinted polymers. New Journal of Chemistry, 34(4) pp. 686–692.

DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1039/B9NJ00538B
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Abstract

Caffeine templated molecularly imprinted polymers (MIPs) have been prepared using identical polymer formulations by thermal and microwave induced initiation, and the binding performance of the systems compared using solid phase extraction (SPE). While the binding capacity of MIP(Microwave) was found to be lower than MIP(Thermal), MIP(Microwave) recorded a higher imprinting factor (IF) due to comparatively low levels of non-specific binding. Selectivity against theophylline in cross-reactivity studies was also found to be greater for MIP(Microwave). While large time savings are achievable through the use of microwave irradiation conditions, physical analysis of the polymers (surface area analysis, thermal gravimetric analysis and differential scanning calorimetry) reveals that the different polymerisation methods lead to differences in both polymer structure and performance.

Item Type: Journal Article
Copyright Holders: 2010 RSC
ISSN: 1144-0546
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Centre for Earth, Planetary, Space and Astronomical Research (CEPSAR)
Biomedical Research Network (BRN)
Item ID: 26991
Depositing User: Nicholas Turner
Date Deposited: 26 Jan 2011 14:42
Last Modified: 10 Mar 2014 09:25
URI: http://oro.open.ac.uk/id/eprint/26991
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