Pontikis, C.; Hudson, L.; Lantos, P.L. and Rezaie, P.
|DOI (Digital Object Identifier) Link:||http://dx.doi.org/10.1046/j.1365-2990.2002.39286_49.x|
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Introduction: Cellular prion protein (PrPc) is a normal glycosyl phosphatidylinositol-anchored protein expressed on a wide variety of cell types. Within the CNS, low levels of PrPc are particularly associated with neurons in normal healthy individuals. In contrast, a more pronounced expression of this protein may occur in certain neurodegenerative disorders (Esiri et al. Neuropath Appl Neurobiol 2000; 26: 273; Voigtlander et al. Acta Neuropathol 2001; 101: 417). Overexpression of PrPc has itself been reported to demonstrate neuropathology in transgenic mice (Westaway et al. Cell 1994; 76: 117). The present study investigated whether prion protein is up-regulated in two well-characterized neurodegenerative disorders: Alzheimer's disease (AD) and diffuse Lewy body disease (DLBD).
|Item Type:||Conference Item|
|Extra Information:||(1)Conference held at the Institute of Child Health.
(2)Abstract published in Neuropathology and Applied Neurobiology April 2002, 28(2):166-167
|Academic Unit/Department:||Science > Life, Health and Chemical Sciences|
|Depositing User:||Payam Rezaie|
|Date Deposited:||18 Jul 2006|
|Last Modified:||02 Dec 2010 19:47|
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