Pontikis, C.; Hudson, L.; Lantos, P.L. and Rezaie, P.
A quantitative analysis of cellular prion protein (PrPc) expression in Alzheimer's disease, diffuse Lewy body disease and in normal brain [poster presentation].
In: Proceedings of the 102nd Meeting of the British Neuropathological Society, 9-11 Jan 2002, London, UK.
Introduction: Cellular prion protein (PrPc) is a normal glycosyl phosphatidylinositol-anchored protein expressed on a wide variety of cell types. Within the CNS, low levels of PrPc are particularly associated with neurons in normal healthy individuals. In contrast, a more pronounced expression of this protein may occur in certain neurodegenerative disorders (Esiri et al. Neuropath Appl Neurobiol 2000; 26: 273; Voigtlander et al. Acta Neuropathol 2001; 101: 417). Overexpression of PrPc has itself been reported to demonstrate neuropathology in transgenic mice (Westaway et al. Cell 1994; 76: 117). The present study investigated whether prion protein is up-regulated in two well-characterized neurodegenerative disorders: Alzheimer's disease (AD) and diffuse Lewy body disease (DLBD).
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