Jeetle, J.K.; Hagger, G.N.; Topps, S.S.; Male, D.K. and Rezaie, P.
Microglial colonization of the developing mouse brain: the effects of CD11b deletion [poster presentation].
Neuropathology and Applied Neurobiology, 28
Introduction: Microglia are resident mononuclear phagocytes of the central nervous system, which colonize the brain both prenatally and after birth. It is proposed that they enter the brain initially via the surrounding mesenchyme, via ventricles and later through blood vessels, but the mechanisms of entry and signals used for migration are still to be established. Previous studies have shown that ligands for some integrin adhesion molecules expressed on blood vessels in the developing nervous system (particularly ICAM-1 and ICAM-2 which bind CD11a/LFA-1 and CD11b/Mac-1), may act as potential recruiting signals for microglial precursors. This study addressed whether CD11b is influential on the migration of microglial precursors into the developing CNS.
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