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The effect of an extract from Ganoderma lucidum (reishi) on the labeling of blood constituents with technetium-99m and on the survival of Escherichia coli

Agostinho, Raquel Terra; David Santos-Filho, S; De Souza da Fonseca, A; Missailidis, Sotiris and Bernardo-Filho, M (2008). The effect of an extract from Ganoderma lucidum (reishi) on the labeling of blood constituents with technetium-99m and on the survival of Escherichia coli. Brazilian Archives of Biology and Technology, 51 pp. 157–163.

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Abstract

This study evaluated effects of an aqueous extract of Ganoderma lucidum (reishi) on the labeling of blood constituents with technetium-99m (99mTc) and on the survival of cultures of Escherichia coli treated with stannous chloride. Blood samples from Wistar rats were treated with reishi extract, radiolabeling procedure was performed, plasma (P), blood cells (BC) and insoluble (IF) and soluble (SF) fractions of P and BC were separated. The radioactivity was counted for the determination of the percentages of radioactivity (%ATI). Cultures of Escherichia coli AB1157 were treated with stannous chloride in the presence and absence of reishi extract. Blood samples and bacterial cultures treated with NaCl 0.9% were used as controls. Data indicated that reishi extract altered significantly (p<0.05) the %ATI of P, BC, IF-P, SF-P, IF-BC and SF-BC, as well as increased the survival of bacterial cultures treated with stannous chloride. Our results suggest that reishi extract could present a redox/chelating action, altering the labeling of blood constituents with 99mTc and protecting bacterial cultures against oxidative damage induced by stannous chloride.

Item Type: Journal Article
Copyright Holders: 2008 Brazilian Archives of Biology and Technology
ISSN: 1516-8913
Keywords: blood constituents; Escherichia coli; Ganoderma lucidum; stannous chloride; technetium-99m
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Related URLs:
Item ID: 26079
Depositing User: Sotiris Missailidis
Date Deposited: 10 Jan 2011 09:39
Last Modified: 10 Mar 2014 11:52
URI: http://oro.open.ac.uk/id/eprint/26079
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