Effect of an extract of Centella asiatica on the biodistribution of sodium pertechnetate (Na^99mTcO₄) and on the fixation of radioactivity on blood constituents

Diniz, Claudia Leite ; Santos Do Carmo, Fernanda ; Santos de Almeida, Danielle ; Missailidis, Sotiris; Santos-Filho, Sebastião David; de Souza da Fonseca, Adenilson and Bernardo-Filho, Mario (2008). Effect of an extract of Centella asiatica on the biodistribution of sodium pertechnetate (Na^99mTcO₄) and on the fixation of radioactivity on blood constituents. Brazilian Archives of Biology and Technology, 51 pp. 215–219.

Full text available as:

Preview

PDF (Version of Record) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader Download (51Kb)

DOI (Digital Object Identifier) Link:	http://dx.doi.org/doi:10.1590/S1516-89132008000700035
Google Scholar:	Look up in Google Scholar

Abstract

This study evaluates the effects of an acute treatment with a Centella asiatica (CA) extract on the biodistribution of the radiopharmaceutical Na^99mTcO4 and on the fixation of technetium-99m on blood constituents. Wistar rats were treated with CA extract and, 1 hour after, Na^99mTcO4 was administered; organs/tissues were withdrawn and weighted. The radioactivity was counted to calculate the percentage of activity per gram (%ATI/g). Also, blood samples were withdrawn, plasma (P), blood cells (BC), insoluble fraction (IF) and soluble fractions of P and BC were isolated and the radioactivity was counted to calculate the percentage of activity (%ATI). Data indicated that the acute treatment with CA extract changed significantly (p<0.05) the %ATI/g in several organs/tissues (spleen, heart, duodenum, stomach, liver, muscle, kidney, testis and blood) and the %ATI on the blood constituents (P, BC, IF-P and IF-BC). These results indicate that the substances or metabolites of the CA extract would change the biodistribution of Na^99mTcO4 and the fixation of the technetium-99m on blood constituents in an acute treatment.

Item Type:	Journal Article
Copyright Holders:	Brazilian Archives of Biology and Technology
ISSN:	1516-8913
Extra Information:	Published in special issue of this volume of this journal
Keywords:	biodistribution; Centella asiatica; blood; plasma; Technetium-99m
Academic Unit/Department:	Science > Life, Health and Chemical Sciences
Item ID:	26052
Depositing User:	Sotiris Missailidis
Date Deposited:	07 Jan 2011 09:54
Last Modified:	27 Oct 2012 16:39
URI:	http://oro.open.ac.uk/id/eprint/26052

Actions (login may be required)

	View Item
RDF+XMLBibTeXRDF+N-TriplesJSONDublin CoreAtomOAI-ORE Resource Map (Atom Format)Simple MetadataReferMETSOAI-ORE Resource Map (RDF Format)HTML CitationASCII CitationMultiline CSVRefMan RIS Format (UTF-8)OpenURL ContextObjectEndNoteMODSOpenURL ContextObject in SpanMPEG-21 DIDLEP3 XMLRefMan RIS FormatRDF+N3Eprints Application Profile	Public: Report issue / request change