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Effect of an extract of Centella asiatica on the biodistribution of sodium pertechnetate (Na99mTcO4) and on the fixation of radioactivity on blood constituents

Diniz, Claudia Leite ; Santos Do Carmo, Fernanda ; Santos de Almeida, Danielle ; Missailidis, Sotiris; Santos-Filho, Sebastião David; de Souza da Fonseca, Adenilson and Bernardo-Filho, Mario (2008). Effect of an extract of Centella asiatica on the biodistribution of sodium pertechnetate (Na99mTcO4) and on the fixation of radioactivity on blood constituents. Brazilian Archives of Biology and Technology, 51 pp. 215–219.

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DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1590/S1516-89132008000700035
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Abstract

This study evaluates the effects of an acute treatment with a Centella asiatica (CA) extract on the biodistribution of the radiopharmaceutical Na99mTcO4 and on the fixation of technetium-99m on blood constituents. Wistar rats were treated with CA extract and, 1 hour after, Na99mTcO4 was administered; organs/tissues were withdrawn and weighted. The radioactivity was counted to calculate the percentage of activity per gram (%ATI/g). Also, blood samples were withdrawn, plasma (P), blood cells (BC), insoluble fraction (IF) and soluble fractions of P and BC were isolated and the radioactivity was counted to calculate the percentage of activity (%ATI). Data indicated that the acute treatment with CA extract changed significantly (p<0.05) the %ATI/g in several organs/tissues (spleen, heart, duodenum, stomach, liver, muscle, kidney, testis and blood) and the %ATI on the blood constituents (P, BC, IF-P and IF-BC). These results indicate that the substances or metabolites of the CA extract would change the biodistribution of Na99mTcO4 and the fixation of the technetium-99m on blood constituents in an acute treatment.

Item Type: Journal Article
Copyright Holders: Brazilian Archives of Biology and Technology
ISSN: 1516-8913
Extra Information: Published in special issue of this volume of this journal
Keywords: biodistribution; Centella asiatica; blood; plasma; Technetium-99m
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 26052
Depositing User: Sotiris Missailidis
Date Deposited: 07 Jan 2011 09:54
Last Modified: 10 Mar 2014 17:54
URI: http://oro.open.ac.uk/id/eprint/26052
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