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Functionalisation of aptamers for the development of effective cancer therapeutics

Makwana, Vaidehi; Khan, Huma; Courtenay-Luck, Nigel and Missailidis, Sotiris (2008). Functionalisation of aptamers for the development of effective cancer therapeutics. Anticancer Research, 28(5C) pp. 3394–3395.

URL: http://ar.iiarjournals.org/content/28/5C
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Abstract

Aptamers, short oligonucleotide therapeutic, diagnostic and imaging agents, possess great affinity and selectivity for their targets. However, they are limited in terms of application due to their rapid renal clearance and degradation from nucleases in the blood. Thus, it is often necessary to incorporate appropriate modifications for achieving their full potential. Aptamer labelling with appropriate fluorescent moieties or radioisotopes can confer diagnostic and imaging potential, respectively. Various chemical modifications, such as PEGylation, can improve their pharmacokinetic properties and retain aptamers longer in circulation, making them suitable for therapeutic applications. We now present a range of chemical modifications on our tumour-targeting aptamers that have allowed us to develop them as diagnostic or therapeutic agents.

Item Type: Journal Article
Copyright Holders: 2008 Anticancer Research
ISSN: 1791-7530
Extra Information: Abstracts of the 8th International Conference of Anticancer Research, 17-22 October 2008, Kos, Greece
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 26045
Depositing User: Sotiris Missailidis
Date Deposited: 09 Jan 2011 12:29
Last Modified: 09 May 2014 12:42
URI: http://oro.open.ac.uk/id/eprint/26045
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