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Methylphenidate amplifies long-term plasticity in the hippocampus via noradrenergic mechanisms

Dommett, Eleanor J.; Henderson, Emma L.; Westwell, Martin S. and Greenfield, Susan A. (2008). Methylphenidate amplifies long-term plasticity in the hippocampus via noradrenergic mechanisms. Learning & Memory, 15(8) pp. 580–586.

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Methylphenidate treatment is used for Attention Deficit Hyperactivity Disorder and can improve learning and memory. Previously, improvements were considered a by-product of increased attention; however, we hypothesize that methylphenidate directly alters mechanisms underlying learning and memory, and therefore examined its effects on hippocampal long-term potentiation and long-term depression. Methylphenidate enhanced both mechanisms in the absence of presynaptic changes and in a noradrenalin β-receptor-dependent manner. These findings can explain both the improved learning and memory and decreased learning selectivity found with methylphenidate treatment and constitute the first demonstration of direct actions of methylphenidate on mechanisms implicated in cognition.

Item Type: Journal Article
Copyright Holders: 2008 Cold Spring Harbor Laboratory Press
ISSN: 1549-5485
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 24717
Depositing User: Ellie Dommett
Date Deposited: 17 Nov 2010 18:29
Last Modified: 07 Mar 2014 13:43
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