Dommett, Eleanor J.; Henderson, Emma L.; Westwell, Martin S. and Greenfield, Susan A.
|DOI (Digital Object Identifier) Link:||http://doi.org/10.1101/lm.1092608|
|Google Scholar:||Look up in Google Scholar|
Methylphenidate treatment is used for Attention Deficit Hyperactivity Disorder and can improve learning and memory. Previously, improvements were considered a by-product of increased attention; however, we hypothesize that methylphenidate directly alters mechanisms underlying learning and memory, and therefore examined its effects on hippocampal long-term potentiation and long-term depression. Methylphenidate enhanced both mechanisms in the absence of presynaptic changes and in a noradrenalin β-receptor-dependent manner. These findings can explain both the improved learning and memory and decreased learning selectivity found with methylphenidate treatment and constitute the first demonstration of direct actions of methylphenidate on mechanisms implicated in cognition.
|Item Type:||Journal Article|
|Copyright Holders:||2008 Cold Spring Harbor Laboratory Press|
|Academic Unit/Department:||Science > Life, Health and Chemical Sciences
|Interdisciplinary Research Centre:||Biomedical Research Network (BRN)|
|Depositing User:||Ellie Dommett|
|Date Deposited:||17 Nov 2010 18:29|
|Last Modified:||15 Jan 2016 15:18|
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