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VUV irradiation studies of plasmid DNA in aqueous solution

Smialek, M. A.; Hoffman, S. V.; Folkard, M.; Prise, K. M.; Shuker, D. E. G.; Braithwaite, N. St. J. and Mason, N. J. (2008). VUV irradiation studies of plasmid DNA in aqueous solution. In: Radiation Damage in Biomolecular Systems (McGuigan, KG ed.), 19-22 July 2007, Dublin, p. 12020.

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Interactions of VUV light and DNA samples in aqueous solutions are reported. The damage induced by such radiation is quantified by monitoring both loss of supercoiled DNA and formation of single and double strand breaks using agarose gel electrophoresis. Irradiations were performed using synchrotron VUV photons of 130, 150, 170 and 190 nm. VUV irradiation experiments revealed enhanced damage upon irradiation with 170 nm photons as compared with irradiations with photons of 150 nm and 130 nm. Irradiations carried at 190 nm caused the least damage.

Item Type: Conference Item
Copyright Holders: 2008 IOP Publishing Ltd
ISSN: 1742-6596
Extra Information: Annual Meeting of the COST P9 Action on Radiation Damage in Biomolecular Systems, Dublin, Ireland, JUL 19-22, 2007

In Journal of Physics: Conference Series, vol.101, 2008
Academic Unit/Department: Science > Physical Sciences
Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Centre for Earth, Planetary, Space and Astronomical Research (CEPSAR)
Item ID: 24601
Depositing User: N St.J Braithwaite
Date Deposited: 11 Nov 2010 09:26
Last Modified: 15 Jan 2016 15:16
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