The Open UniversitySkip to content

UVA light-assisted anticancer drugs - study on 4-thiothymidine and its analogues

Zhang, X. H.; Wang, A. L.; Li, D. P. and Xu, Y.-Z. (2010). UVA light-assisted anticancer drugs - study on 4-thiothymidine and its analogues. Progress in Chemistry, 22(5) pp. 784–795.

Full text available as:
[img] PDF (Version of Record) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Download (640kB)
Google Scholar: Look up in Google Scholar


The article reviews the chemical methods for the preparation of DNA containing 4-thiothymine. 4-Thiothymine has several unique properties, such as easy alkylation, ready oxidation and strong absorption in UVA region. These chemical and physical properties are retained at its nucleoside and DNA levels and particularly useful for chemical manipulation and photo crossing of the thiothymine DNA with other biomolecules of interest. The ability to make DNA containing thiothymine or their functionalized analogues is also useful for studying DNA repairs. UVA/thiothymidine anti-cancer therapy is also introduced and discussed. The synergetic exploration of sulfur-containing nucleoside analogues and ultraviolet light could provide a new way for treatment of cancer.

Item Type: Journal Item
Copyright Holders: 2010 Editorial Office of Progress in Chemistry
ISSN: 1005-281X
Extra Information: In Chinese.
Keywords: thiothymidine; modified bases; DNA repair; anticancer drugs; photodynamic therapy ( PDT)
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Related URLs:
Item ID: 24430
Depositing User: Yao Xu
Date Deposited: 20 Jan 2012 16:40
Last Modified: 08 Dec 2018 05:35
Share this page:

Download history for this item

These details should be considered as only a guide to the number of downloads performed manually. Algorithmic methods have been applied in an attempt to remove automated downloads from the displayed statistics but no guarantee can be made as to the accuracy of the figures.

Actions (login may be required)

Policies | Disclaimer

© The Open University   contact the OU