Zhang, X. H.; Wang, A. L.; Li, D. P. and Xu, Y.-Z.
UVA light-assisted anticancer drugs - study on 4-thiothymidine and its analogues.
Progress in Chemistry, 22(5)
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The article reviews the chemical methods for the preparation of DNA containing 4-thiothymine. 4-Thiothymine has several unique properties, such as easy alkylation, ready oxidation and strong absorption in UVA region. These chemical and physical properties are retained at its nucleoside and DNA levels and particularly useful for chemical manipulation and photo crossing of the thiothymine DNA with other biomolecules of interest. The ability to make DNA containing thiothymine or their functionalized analogues is also useful for studying DNA repairs. UVA/thiothymidine anti-cancer therapy is also introduced and discussed. The synergetic exploration of sulfur-containing nucleoside analogues and ultraviolet light could provide a new way for treatment of cancer.
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