The Open UniversitySkip to content

A subpopulation of serotonin1B receptors colocalize with the AMPA receptor subunit GluR2 in the hippocampal dentate gyrus

Peddie, C. J.; Davies, H. A.; Colyer, F M.; Stewart, M. G. and Rodríguez, J. J. (2010). A subpopulation of serotonin1B receptors colocalize with the AMPA receptor subunit GluR2 in the hippocampal dentate gyrus. Neuroscience Letters, 485(3) pp. 251–255.

Full text available as:
Full text not publicly available (Version of Record)
Due to publisher licensing restrictions, this file is not available for public download
DOI (Digital Object Identifier) Link:
Google Scholar: Look up in Google Scholar


The serotonin1B receptor (5-HT1BR) plays a role in cognitive processes that also involve glutamatergic neurotransmission via amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) receptors. Accumulating experimental evidence also highlights the involvement of 5-HT1BRs in several neurological disorders. Consequently, the 5-HT1BR is increasingly implicated as a potential therapeutic target for intervention in cognitive dysfunction. Within the hippocampus, a brain region critical to cognitive processing, populations of pre- and post-synaptic 5-HT1BRs have been identified. Thus, 5-HT<sub1B</sub>Rs could have a role in the modulation of hippocampal pre- and post-synaptic conductance. Previously, we demonstrated colocalization of 5-HT1BRs with the N-methyl-d-aspartate (NMDA) receptor subunit NR1 in a subpopulation of granule cell dendrites (Peddie et al. [53]). In this study, we have examined the cellular and subcellular distribution of 5-HT1BRs with the AMPA receptor subunit GluR2. Of 5-HT1BR positive profiles, 28% displayed colocalization with GluR2. Of these, 87% were dendrites, corresponding to 41% and 10% of all 5-HT1BR labeled or GluR2 labeled dendrites, respectively. Dendritic labeling was both cytoplasmic and membranous but was not usually associated with synaptic sites. Colocalization within dendritic spines and axons was comparatively rare. These findings indicate that within the dentate gyrus molecular layer, dendritic 5-HT1BRs are expressed predominantly on GluR2 negative granule cell processes. However, a subpopulation of 5-HT1BRs is expressed on GluR2 positive dendrites. Here, it is suggested that activation of the 5-HT1BR may play a role in the modulation of AMPA receptor mediated conductance, further supporting the notion that the 5-HT1BR represents an interesting therapeutic target for modulation of cognitive function.

Item Type: Journal Item
Copyright Holders: 2010 Elsevier Ireland Ltd
ISSN: 0304-3940
Keywords: serotonin; hippocampus; glutamate; localization; ultrastructure; 5-HT1BR; GluR2; receptor
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 24258
Depositing User: Astrid Peterkin
Date Deposited: 01 Nov 2010 12:18
Last Modified: 26 Jun 2020 17:11
Share this page:


Altmetrics from Altmetric

Citations from Dimensions

Actions (login may be required)

Policies | Disclaimer

© The Open University   contact the OU