Dourado, Inês; Cunha, Sérgio; Teixeira, Maria de Gloria; Farrington, C. Paddy; Melo, Ailton; Lucena, Rita and Barreto, Mauricio L.
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A mass immunization campaign with a Urabe-containing measles-mumps-rubella vaccine was carried out in 1997 in the city of Salvador, northeastern Brazil, with a target population of children aged 1–11 years. There was an outbreak of aseptic meningitis following the mass campaign. Cases of aseptic meningitis were ascertained through data collected from the records of children admitted to the local referral hospital for infectious diseases between March and October of 1997, using previously defined eligibility criteria. Vaccination histories were obtained through home visits of telephone calls. Eighty-seven cases fulfilled the study criteria. Of those, 58 cases were diagnosed after the vaccination campaign. An elevated risk of aseptic meningitis was observed 3 weeks after Brazil's national vaccination day compared with the risk in the prevaccination period (relative risk = 14.3; 95% confidence interval: 7.9, 25.7). This result was confirmed by a case series analysis (relative risk = 30.4; 95% confidence interval: 11.5, 80.8). The estimated risk of aseptic meningitis was 1 in 14, 000 doses. This study confirms a link between measles-mumps-rubella vaccination and aseptic meningitis. The authors discuss the implications of this for the organization and planning of mass immunization campaigns.
|Item Type:||Journal Article|
|Copyright Holders:||2000 The Johns Hopkins University School of Hygiene and Public Health|
|Keywords:||disease outbreaks; meningitis; aseptic; mumps vaccine; product surveillance; postmarketing; vaccines|
|Academic Unit/Department:||Mathematics, Computing and Technology > Mathematics and Statistics|
|Depositing User:||Sarah Frain|
|Date Deposited:||05 Apr 2011 12:52|
|Last Modified:||26 Mar 2014 15:02|
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