The Open UniversitySkip to content
 

Transient expression of MIDC-8 in the normal mouse brain

Rezaie, Payam; Corbisiero, Vanessa and Male, David (2005). Transient expression of MIDC-8 in the normal mouse brain. Neuroscience Letters, 377(3) pp. 189–194.

DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1016/j.neulet.2004.12.002
Google Scholar: Look up in Google Scholar

Abstract

In this study, we have immunohistochemically characterized the expression of mononuclear phagocyte markers CD14, CD36, CD68, CD204 and MARCO by parenchymal microglia in the developing and adult mouse brain. We further investigated whether these cells express two well-characterized phenotypic markers of dendritic cells: CD205 (DEC-205/NLDC-145) and MIDC-8 antigen. Our results confirm the lack of expression of dendritic cell markers by microglia. We noted that these cells do not appear to express markers associated with monocytes and macrophages during the course of development, but do express CD68 and CD204 antigens in the adult. Unexpectedly, we also noted the transient expression of MIDC-8 antigen on cells within the medial ganglionic eminence and by neuroepithelial cells lining the lateral ventricles and in the medial lemniscus between E15 and E19. We discuss this finding in the context of neural and haematopoietic differentiation.

Item Type: Journal Article
ISSN: 0304-3940
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Innovation, Knowledge & Development research centre (IKD)
Item ID: 2342
Depositing User: Payam Rezaie
Date Deposited: 14 Jun 2006
Last Modified: 07 Mar 2014 13:39
URI: http://oro.open.ac.uk/id/eprint/2342
Share this page:

Altmetrics

Scopus Citations

Actions (login may be required)

View Item
Report issue / request change

Policies | Disclaimer

© The Open University   + 44 (0)870 333 4340   general-enquiries@open.ac.uk