The Open UniversitySkip to content
 

Antioxidant and cytoprotective responses to redox stress

Mathers, Joanne; Fraser, Jennifer A.; McMahon, Michael; Saunders, Robert D.C.; Hayes, John D. and McLellan, Lesley I. (2004). Antioxidant and cytoprotective responses to redox stress. Biochemistry Society Symposia, 71(13) pp. 157–176.

URL: http://symposia.biochemistry.org/bssymp/071/bss071...
Google Scholar: Look up in Google Scholar

Abstract

Aerobic cells produce reactive oxygen species as a consequence of normal cellular metabolism, and an array of antioxidant systems are in place to maintain the redox balance. When the redox equilibrium of the cell is upset by pro-oxidant environmental stimuli, adaptive responses to the redox stress take place, which can result in up-regulation of antioxidant proteins and detoxification enzymes. Over the past few years, it has become apparent that members of the CNC (cap 'n' collar)-basic leucine zipper family of transcription factors are principal mediators of defensive responses to redox stress. In mammals, the CNC family members nuclear factor-erythroid 2 p45-related factors 1 and 2 (Nrf1 and Nrf2) have been shown to be involved in the transcriptional up-regulation of cytoprotective genes including those encoding glutamate cysteine ligase, NAD(P)H:quinone oxidoreductase, glutathione S-transferases and aldo-keto reductases. An evolutionarily conserved system exists in Caenorhabditis elegans, and it is possible that Drosophila melanogaster may also utilize CNC transcription factors to induce antioxidant genes in response to pro-oxidant chemicals. The advent of microarray and proteomic technologies has advanced our understanding of the gene batteries regulated by oxidative insult, but has highlighted the complexity of gene regulation by environmental factors. This review focuses on the antioxidant response to environmental stress, and the impact that microarrays and proteomics have made in this field.

Item Type: Journal Article
ISSN: 0067-8694
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 2305
Depositing User: Robert Saunders
Date Deposited: 12 Jun 2006
Last Modified: 10 Mar 2014 09:28
URI: http://oro.open.ac.uk/id/eprint/2305
Share this page:

Actions (login may be required)

View Item
Report issue / request change

Policies | Disclaimer

© The Open University   + 44 (0)870 333 4340   general-enquiries@open.ac.uk