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Synthesis and biological activity of 2-anilino-4-(1H-pyrrol-3-yl) pyrimidine CDK inhibitors

Wang, Shudong; Wood, Gavin; Meades, Christopher; Griffiths, Gary; Midgley, Carol; McNae, Ian; McInnes, Campbell; Anderson, Sian; Jackson, Wayne; Mezna, Mokdad; Yuill, Rhoda; Walkinshaw, Malcolm and Fischer, Peter M. (2004). Synthesis and biological activity of 2-anilino-4-(1H-pyrrol-3-yl) pyrimidine CDK inhibitors. Bioorganic and Medicinal Chemistry Letters, 14(16) pp. 4237–4240.

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A series of 2-anilino-4-(1H-pyrrol-3-yl)pyrimidines were prepared and evaluated for their ability to inhibit cyclin-dependent kinases (CDKs). A number of analogues were found to be potent CDK2 and CDK4 inhibitors and to exhibit anti-proliferative activity against human tumour cell lines. Structure-activity relationships and biochemical characterization are presented.

Item Type: Journal Article
ISSN: 0960-894X
Extra Information: Some of the symbols may not have transferred correctly into this bibliographic record and/or abstract.
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 2298
Depositing User: Carol Midgley
Date Deposited: 12 Jun 2006
Last Modified: 14 Jan 2016 15:47
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