Wang, Shudong; Wood, Gavin; Meades, Christopher; Griffiths, Gary; Midgley, Carol; McNae, Ian; McInnes, Campbell; Anderson, Sian; Jackson, Wayne; Mezna, Mokdad; Yuill, Rhoda; Walkinshaw, Malcolm and Fischer, Peter M.
|DOI (Digital Object Identifier) Link:||http://doi.org/10.1016/j.bmcl.2004.06.012|
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A series of 2-anilino-4-(1H-pyrrol-3-yl)pyrimidines were prepared and evaluated for their ability to inhibit cyclin-dependent kinases (CDKs). A number of analogues were found to be potent CDK2 and CDK4 inhibitors and to exhibit anti-proliferative activity against human tumour cell lines. Structure-activity relationships and biochemical characterization are presented.
|Item Type:||Journal Article|
|Extra Information:||Some of the symbols may not have transferred correctly into this bibliographic record and/or abstract.
|Academic Unit/Department:||Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
|Interdisciplinary Research Centre:||Biomedical Research Network (BRN)|
|Depositing User:||Carol Midgley|
|Date Deposited:||12 Jun 2006|
|Last Modified:||02 Aug 2016 12:52|
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