Synthesis and biological activity of 2-anilino-4-(1H-pyrrol-3-yl) pyrimidine CDK inhibitors

Wang, Shudong; Wood, Gavin; Meades, Christopher; Griffiths, Gary; Midgley, Carol; McNae, Ian; McInnes, Campbell; Anderson, Sian; Jackson, Wayne; Mezna, Mokdad; Yuill, Rhoda; Walkinshaw, Malcolm and Fischer, Peter M. (2004). Synthesis and biological activity of 2-anilino-4-(1H-pyrrol-3-yl) pyrimidine CDK inhibitors. Bioorganic and Medicinal Chemistry Letters, 14(16) pp. 4237–4240.

DOI: https://doi.org/10.1016/j.bmcl.2004.06.012

URL: http://www.sciencedirect.com/science?_ob=ArticleUR...

Abstract

A series of 2-anilino-4-(1H-pyrrol-3-yl)pyrimidines were prepared and evaluated for their ability to inhibit cyclin-dependent kinases (CDKs). A number of analogues were found to be potent CDK2 and CDK4 inhibitors and to exhibit anti-proliferative activity against human tumour cell lines. Structure-activity relationships and biochemical characterization are presented.

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