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Estimation of effective reproduction numbers for infectious diseases using serological survey data

Farrington, C.P. and Whitaker, H.J. (2003). Estimation of effective reproduction numbers for infectious diseases using serological survey data. Biostatistics, 4(4) pp. 621–632.

DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1093/biostatistics/4.4.621
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Abstract

The effective reproduction number of an infection, denoted Re, may be used to monitor the impact of a vaccination programme. If Re is maintained below 1, then sustained endemic transmission of the infection cannot occur. In this paper we discuss methods for estimating Re from serological survey data, allowing for age and individual heterogeneity. We describe semi-parametric and parametric models, and obtain an upper bound on Re when vaccine coverage and efficacy are not known. The methods are illustrated using data on mumps and rubella in England and Wales.

Item Type: Journal Article
ISSN: 1468-4357
Keywords: Eigenvalue; Frailty; Infectious disease; Reproduction number; Vaccine
Academic Unit/Department: Mathematics, Computing and Technology > Mathematics and Statistics
Item ID: 2268
Depositing User: Heather Whitaker
Date Deposited: 12 Jun 2006
Last Modified: 02 Dec 2010 19:47
URI: http://oro.open.ac.uk/id/eprint/2268
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