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Changes in age-related seroprevalence of antibody to varicella-zoster virus: impact on vaccine strategy

Kudesia, G.; Partridge, S.; Farrington, C. P. and Soltanpoor, N. (2002). Changes in age-related seroprevalence of antibody to varicella-zoster virus: impact on vaccine strategy. Journal of Clinical Pathology, 55(2) pp. 154–155.

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Abstract

Aim: To study changes in the seroprevalence of varicella zoster virus (VZV) antibody over the past 25 years with a view to determining the target age group for any future vaccination strategy.
Methods: Stored sera collected from different age groups over a period of 25 years were tested by a commercial VZV IgG enzyme immunoassay at a four year time interval. Data were analysed by logistic regression to investigate the evidence for changes in incidence and hence seroprevalence over that period.
Results: There was a significant rise in VZV antibody prevalence in the 1–4 year age group during the study period.
Conclusions: A universal childhood VZV vaccination strategy will need to take account of the increase in incidence of VZV infection in children under the age of 4 years; hence, the suggested target age would be between 12 and 18 months–soon after the disappearance of maternal antibody.

Item Type: Journal Article
Copyright Holders: 2002 The Authors
ISSN: 0021-9746
Academic Unit/Department: Mathematics, Computing and Technology > Mathematics and Statistics
Item ID: 22671
Depositing User: Sarah Frain
Date Deposited: 11 Aug 2010 11:09
Last Modified: 23 Jan 2011 05:06
URI: http://oro.open.ac.uk/id/eprint/22671
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