Kudesia, G.; Partridge, S.; Farrington, C. P. and Soltanpoor, N.
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Aim: To study changes in the seroprevalence of varicella zoster virus (VZV) antibody over the past 25 years with a view to determining the target age group for any future vaccination strategy.
Methods: Stored sera collected from different age groups over a period of 25 years were tested by a commercial VZV IgG enzyme immunoassay at a four year time interval. Data were analysed by logistic regression to investigate the evidence for changes in incidence and hence seroprevalence over that period.
Results: There was a significant rise in VZV antibody prevalence in the 1–4 year age group during the study period.
Conclusions: A universal childhood VZV vaccination strategy will need to take account of the increase in incidence of VZV infection in children under the age of 4 years; hence, the suggested target age would be between 12 and 18 months–soon after the disappearance of maternal antibody.
|Item Type:||Journal Article|
|Copyright Holders:||2002 The Authors|
|Academic Unit/Department:||Mathematics, Computing and Technology > Mathematics and Statistics|
|Depositing User:||Sarah Frain|
|Date Deposited:||11 Aug 2010 11:09|
|Last Modified:||23 Jan 2011 05:06|
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