Kudesia, G.; Partridge, S.; Farrington, C. P. and Soltanpoor, N.
(2002).
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| URL: | http://jcp.bmjjournals.com/content/55/2/154.full |
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Abstract
Aim: To study changes in the seroprevalence of varicella zoster virus (VZV) antibody over the past 25 years with a view to determining the target age group for any future vaccination strategy.
Methods: Stored sera collected from different age groups over a period of 25 years were tested by a commercial VZV IgG enzyme immunoassay at a four year time interval. Data were analysed by logistic regression to investigate the evidence for changes in incidence and hence seroprevalence over that period.
Results: There was a significant rise in VZV antibody prevalence in the 1–4 year age group during the study period.
Conclusions: A universal childhood VZV vaccination strategy will need to take account of the increase in incidence of VZV infection in children under the age of 4 years; hence, the suggested target age would be between 12 and 18 months–soon after the disappearance of maternal antibody.
| Item Type: | Journal Article |
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| Copyright Holders: | 2002 The Authors |
| ISSN: | 0021-9746 |
| Academic Unit/Department: | Faculty of Science, Technology, Engineering and Mathematics (STEM) > Mathematics and Statistics Faculty of Science, Technology, Engineering and Mathematics (STEM) |
| Item ID: | 22671 |
| Depositing User: | Sarah Frain |
| Date Deposited: | 11 Aug 2010 11:09 |
| Last Modified: | 07 Aug 2016 16:24 |
| URI: | http://oro.open.ac.uk/id/eprint/22671 |
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