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Kudesia, G.; Partridge, S.; Farrington, C. P. and Soltanpoor, N.
(2002).
URL: http://jcp.bmjjournals.com/content/55/2/154.full
Abstract
Aim: To study changes in the seroprevalence of varicella zoster virus (VZV) antibody over the past 25 years with a view to determining the target age group for any future vaccination strategy.
Methods: Stored sera collected from different age groups over a period of 25 years were tested by a commercial VZV IgG enzyme immunoassay at a four year time interval. Data were analysed by logistic regression to investigate the evidence for changes in incidence and hence seroprevalence over that period.
Results: There was a significant rise in VZV antibody prevalence in the 1–4 year age group during the study period.
Conclusions: A universal childhood VZV vaccination strategy will need to take account of the increase in incidence of VZV infection in children under the age of 4 years; hence, the suggested target age would be between 12 and 18 months–soon after the disappearance of maternal antibody.
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- Item ORO ID
- 22671
- Item Type
- Journal Item
- ISSN
- 0021-9746
- Academic Unit or School
-
Faculty of Science, Technology, Engineering and Mathematics (STEM) > Mathematics and Statistics
Faculty of Science, Technology, Engineering and Mathematics (STEM) - Copyright Holders
- © 2002 The Authors
- Depositing User
- Sarah Frain