Lack of association between intussusception and oral polio vaccine in Cuban children

Galindo Sardinas, Miguel A.; Zambrano Cardenas, Andrés; Coutin Marie, Gisele; Santin Pena, Manuel; Alino Santiago, Miriam; Valcarcel Sanchez, Marlen and Farrington, C. P. (2001). Lack of association between intussusception and oral polio vaccine in Cuban children. European Journal of Epidemiology, 17(8) pp. 783–787.

DOI: https://doi.org/10.1023/A:1015675932509

Abstract

Two exploratory investigations found an increased risk of intussusception after oral polio vaccine (OPV). A large, national, population-based study was undertaken in Cuba to investigate a possible association. Three hundred and thirty-five cases of intussusception in children under 2 years of age occurring in 1995–2000 were identified and their OPV records retrieved. The relative incidence (RI) of intussusception in defined periods up to 42 days after OPV in children under 1 year was estimated using the self-controlled case series method, controlling for age and season. The RI was not significantly raised in any of the time intervals examined within the 0–42 day period after OPV. For the period 0–42 days as a whole the RI was 1.11, 95% CI 0.74–1.67. This study does not support the hypothesis that OPV causes intussusception.

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About

• Item ORO ID
• 22660
• Item Type
• Journal Item
• ISSN
• 0393-2990
• Keywords
• case series analysis; epidemiology; intussusception; oral polio vaccine; vaccine reaction; vaccine safety
• Academic Unit or School
• Faculty of Science, Technology, Engineering and Mathematics (STEM) > Mathematics and Statistics
  Faculty of Science, Technology, Engineering and Mathematics (STEM)
• Copyright Holders
• © 2002 Kluwer Academic Publishers
• Depositing User
• Sarah Frain