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Re: Risk analysis of aseptic meningitis after measles-mumps-rubella vaccination in Korean children by using a case-crossover design (letter)

Farrington, Paddy (2004). Re: Risk analysis of aseptic meningitis after measles-mumps-rubella vaccination in Korean children by using a case-crossover design (letter). American Journal of Epidemiology, 159 pp. 717–718.

DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1093/aje/kwh093
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Abstract

Ki et al. used a case-crossover design to evaluate the relative risk of aseptic meningitis after measles-mumps-rubella vaccination. Although their results are broadly in line with those of others on the same topic, the case-crossover design cannot generally be recommended for investigating associations between adverse events and childhood immunizations because it requires the probability of exposure (i.e., vaccination) to be constant over time. This requirement is certainly not met by childhood immunizations administered according to highly age-dependent schedules. Measles-mumps-rubella vaccines, for example, are typically given at 12–15 months of age.

Item Type: Journal Article
Copyright Holders: 2004 The Author
ISSN: 1476-6256
Academic Unit/Department: Mathematics, Computing and Technology > Mathematics and Statistics
Item ID: 22610
Depositing User: Sarah Frain
Date Deposited: 15 Sep 2010 15:21
Last Modified: 26 Mar 2014 14:55
URI: http://oro.open.ac.uk/id/eprint/22610
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