Re: Risk analysis of aseptic meningitis after measles-mumps-rubella vaccination in Korean children by using a case-crossover design (letter).
American Journal of Epidemiology, 159 pp. 717–718.
Ki et al. used a case-crossover design to evaluate the relative risk of aseptic meningitis after measles-mumps-rubella vaccination. Although their results are broadly in line with those of others on the same topic, the case-crossover design cannot generally be recommended for investigating associations between adverse events and childhood immunizations because it requires the probability of exposure (i.e., vaccination) to be constant over time. This requirement is certainly not met by childhood immunizations administered according to highly age-dependent schedules. Measles-mumps-rubella vaccines, for example, are typically given at 12–15 months of age.
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