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The methodology of self-controlled case series studies

Whitaker, Heather J.; Hocine, Mounia N. and Farrington, C. Paddy (2009). The methodology of self-controlled case series studies. Statistical Methods in Medical Research, 18(1) pp. 7–26.

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DOI (Digital Object Identifier) Link: http://doi.org/10.1177/0962280208092342
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Abstract

The self-controlled case series method is increasingly being used in pharmacoepidemiology, particularly in vaccine safety studies. This method is typically used to evaluate the association between a transient exposure and an acute event, using only cases. We present both parametric and semiparametric models using a motivating example on MMR vaccine and bleeding disorders. We briefly describe approaches for interferent events and a sequential version of the method for prospective surveillance of drug safety. The efficiency of the self-controlled case series method is compared to the that of cohort and case control studies. Some further extensions, to long or indefinite exposures and to bivariate counts, are described.

Item Type: Journal Article
Copyright Holders: 2009 SAGE Publications
ISSN: 1477-0334
Academic Unit/Department: Mathematics, Computing and Technology > Mathematics and Statistics
Mathematics, Computing and Technology
Item ID: 22512
Depositing User: Sarah Frain
Date Deposited: 10 Aug 2010 10:29
Last Modified: 23 Feb 2016 19:52
URI: http://oro.open.ac.uk/id/eprint/22512
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