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New methodologies for the synthesis of 3-acylpyridone metabolites

Jones, Raymond C. F.; Choudhury, Abdul K.; Iley, James N.; Loizou, Georgia; Lumley, Christopher and McKee, Vickie (2010). New methodologies for the synthesis of 3-acylpyridone metabolites. Synlett(4) pp. 654–658.

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A core isoxazolo[4,3-c]pyridin-4-one scaffold is prepared and elaborated at C-3(Me) and C-7 as a masked building block for 3-acylpyridin-2-ones related to the acylpyridone natural products.

Item Type: Journal Article
Copyright Holders: 2010 Georg Thieme Verlag Stuttgart
ISSN: 0936-5214
Keywords: heterocycles; cycloaddition; metalation; aldol reaction; pyridone
Academic Unit/Department: Science
Item ID: 20972
Depositing User: James Iley
Date Deposited: 06 Apr 2010 15:18
Last Modified: 15 Jan 2016 12:39
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