New methodologies for the synthesis of 3-acylpyridone metabolites

Jones, Raymond C. F.; Choudhury, Abdul K.; Iley, James N.; Loizou, Georgia; Lumley, Christopher and McKee, Vickie (2010). New methodologies for the synthesis of 3-acylpyridone metabolites. Synlett(4), pp. 654–658.

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DOI (Digital Object Identifier) Link:	http://dx.doi.org/doi:10.1055/s-0029-1219341
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Abstract

A core isoxazolo[4,3-c]pyridin-4-one scaffold is prepared and elaborated at C-3(Me) and C-7 as a masked building block for 3-acylpyridin-2-ones related to the acylpyridone natural products.

Item Type:	Journal Article
Copyright Holders:	2010 Georg Thieme Verlag Stuttgart
ISSN:	0936-5214
Keywords:	heterocycles; cycloaddition; metalation; aldol reaction; pyridone
Academic Unit/Department:	Science > Life, Health and Chemical Sciences
Item ID:	20972
Depositing User:	James Iley
Date Deposited:	06 Apr 2010 15:18
Last Modified:	14 Nov 2012 12:22
URI:	http://oro.open.ac.uk/id/eprint/20972

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