The Open UniversitySkip to content
 

Colostrinin™ alleviates amyloid-β induced toxicity in rat primary hippocampal cultures

Froud, Kristina E.; Wardhaugh, Tina; Banks, Duncan; Saffrey, M. Jill and Stewart, Michael G. (2010). Colostrinin™ alleviates amyloid-β induced toxicity in rat primary hippocampal cultures. Journal of Alzheimer's Disease, 20(2) pp. 423–426.

Full text available as:
[img]
Preview
PDF (Accepted Manuscript) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Download (223Kb)
DOI (Digital Object Identifier) Link: http://dx.doi.org/10.3233/JAD-2010-1382
Google Scholar: Look up in Google Scholar

Abstract

Colostrinin™ (CLN), a complex mixture of proline-rich polypeptides derived from colostrums, can alleviate cognitive decline in early Alzheimer's disease patients. The molecular basis of the action of CLN has been studied in vitro using human neuroblastoma cell lines. The aim of the present study was to use quantitative immunocytochemistry and immunoblotting to investigate the ability of CLN to relieve amyloid-β (Aβ)-induced cytotoxicity in rat primary hippocampal neuronal cells. Our data confirm that CLN alleviates the effect of Aβ-induced cytotoxicity and causes a significant reduction in the elevated levels of the antioxidant enzyme SOD1.

Item Type: Journal Article
Copyright Holders: 2010 IOS Press
ISSN: 1387-2877
Keywords: Alzheimer's disease; amyloid-β; colostrinin; hippocampus; oxidative stress; superoxide dismutase
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Science
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 20163
Depositing User: Colin Smith
Date Deposited: 26 Feb 2010 12:20
Last Modified: 10 Mar 2014 17:46
URI: http://oro.open.ac.uk/id/eprint/20163
Share this page:

Actions (login may be required)

View Item
Report issue / request change

Policies | Disclaimer

© The Open University   + 44 (0)870 333 4340   general-enquiries@open.ac.uk