Froud, Kristina E.; Wardhaugh, Tina; Banks, Duncan; Saffrey, M. Jill and Stewart, Michael G.
PDF (Accepted Manuscript)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
|DOI (Digital Object Identifier) Link:||http://doi.org/10.3233/JAD-2010-1382|
|Google Scholar:||Look up in Google Scholar|
Colostrinin™ (CLN), a complex mixture of proline-rich polypeptides derived from colostrums, can alleviate cognitive decline in early Alzheimer's disease patients. The molecular basis of the action of CLN has been studied in vitro using human neuroblastoma cell lines. The aim of the present study was to use quantitative immunocytochemistry and immunoblotting to investigate the ability of CLN to relieve amyloid-β (Aβ)-induced cytotoxicity in rat primary hippocampal neuronal cells. Our data confirm that CLN alleviates the effect of Aβ-induced cytotoxicity and causes a significant reduction in the elevated levels of the antioxidant enzyme SOD1.
|Item Type:||Journal Article|
|Copyright Holders:||2010 IOS Press|
|Keywords:||Alzheimer's disease; amyloid-β; colostrinin; hippocampus; oxidative stress; superoxide dismutase|
|Academic Unit/Department:||Science > Life, Health and Chemical Sciences
|Interdisciplinary Research Centre:||Biomedical Research Network (BRN)|
|Depositing User:||Colin Smith|
|Date Deposited:||26 Feb 2010 12:20|
|Last Modified:||23 Feb 2016 21:30|
|Share this page:|
Download history for this item
These details should be considered as only a guide to the number of downloads performed manually. Algorithmic methods have been applied in an attempt to remove automated downloads from the displayed statistics but no guarantee can be made as to the accuracy of the figures.