Stewart, Michael; Popov, Victor; Medvedev, Nikolay; Gabbott, Paul; Corbett, Nicola; Kraev, Igor and Davies, Heather
(2010).
| DOI (Digital Object Identifier) Link: | http://dx.doi.org/doi:10.1007/978-1-4419-1170-4 |
|---|---|
| Google Scholar: | Look up in Google Scholar |
Abstract
The neural cell adhesion molecule (NCAM) is a membrane-associated glycoprotein expressed on the surface of neurons and glial cells and is also a member of the immunoglobin (Ig) superfamily. It promotes synaptogenesis, enhances presynaptic function, and facilitates synaptic plasticity in relation to learning and memory consolidation. This short review will focus on evidence of the role of NCAMs in synaptic plasticity and learning, and the ability of an NCAM mimetic to influence morphological changes in dendritic spines and synapses.
| Item Type: | Book Chapter |
|---|---|
| Copyright Holders: | 2010 Springer Science + Business Media, LLC |
| ISBN: | 1-4419-1169-3, 978-1-4419-1169-8 |
| Keywords: | dendritic spine; PSD; 3D reconstruction; ultrastructure; NCAM-mimetic |
| Academic Unit/Department: | Science > Life, Health and Chemical Sciences Science |
| Interdisciplinary Research Centre: | Centre for Research in Computing (CRC) |
| Item ID: | 20162 |
| Depositing User: | Colin Smith |
| Date Deposited: | 26 Feb 2010 12:04 |
| Last Modified: | 16 Nov 2012 14:07 |
| URI: | http://oro.open.ac.uk/id/eprint/20162 |
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