Harada, Yosuke; Okabe, Chie; Kobayashi, Takashi; Suzuki, Tadashi; Ichimura, Teijiro; Nishi, Nobuyuki and Xu, Yao-Zhong
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|DOI (Digital Object Identifier) Link:||http://dx.doi.org/10.1021/jz900276x|
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Ultrafast intersystem crossing of UVA-sensitive 4-thiothymidine in aqueous solution was investigated by pump?probe transient absorption. 4-Thiothymidine in the excited singlet state exhibited a distinctively different photophysical pathway from that of thymidine, with intersystem crossing to the triplet manifold being dominant and the triplet formation being completed within approximately 10 ps. This was further supported by quantum chemical calculations. We propose that the unique behavior of photoexcited 4-thiothymidine results from its distinctive molecular and electronic structures and that the triplet form is the initial toxic source to DNA and other biomolecules.
|Item Type:||Journal Article|
|Copyright Holders:||2010 American Chemical Society|
|Academic Unit/Department:||Science > Life, Health and Chemical Sciences|
|Depositing User:||Astrid Peterkin|
|Date Deposited:||09 Feb 2010 12:19|
|Last Modified:||26 Nov 2012 17:39|
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