Immortalized Human Brain Endothelial Cell Line HCMEC/D3 as a Model of the Blood-Brain Barrier Facilitates In Vitro Studies of Central Nervous System Infection by Cryptococcus neoformans

Vu, Kiem; Weksler, Babette; Romero, Ignacio A; Couraud, Pierre-Olivier and Gelli, Angie (2009). Immortalized Human Brain Endothelial Cell Line HCMEC/D3 as a Model of the Blood-Brain Barrier Facilitates In Vitro Studies of Central Nervous System Infection by Cryptococcus neoformans. Eukaryotic Cell, 8(11) pp. 1803–1807.

DOI: https://doi.org/10.1128/EC.00240-09

Abstract

Cryptococcus neoformans cells must cross the blood-brain barrier prior to invading the central nervous system. Here we demonstrate that the immortalized human brain endothelial cell line HCMEC/D3 is a useful alternative to primary brain endothelial cells as a model of the blood-brain barrier for studies of central nervous system infection.

Viewing alternatives

Metrics

Item Actions

Export

You can export this page using these formats Digital Object Identifier - DOI

About

• Item ORO ID
• 19390
• Item Type
• Journal Item
• ISSN
• 1535-9786
• Keywords
• Cryptococcus neoformans cells; CNS; central nervous system; endothelial cells; blood-brain barrier
• Academic Unit or School
• Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
  Faculty of Science, Technology, Engineering and Mathematics (STEM)
• Copyright Holders
• © 2009 American Society for Microbiology
• Depositing User
• Users 9108 not found.