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Immortalized Human Brain Endothelial Cell Line HCMEC/D3 as a Model of the Blood-Brain Barrier Facilitates In Vitro Studies of Central Nervous System Infection by Cryptococcus neoformans

Vu, Kiem; Weksler, Babette; Romero, Ignacio A; Couraud, Pierre-Olivier and Gelli, Angie (2009). Immortalized Human Brain Endothelial Cell Line HCMEC/D3 as a Model of the Blood-Brain Barrier Facilitates In Vitro Studies of Central Nervous System Infection by Cryptococcus neoformans. Eukaryotic Cell, 8(11) pp. 1803–1807.

DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1128/EC.00240-09
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Abstract

Cryptococcus neoformans cells must cross the blood-brain barrier prior to invading the central nervous system. Here we demonstrate that the immortalized human brain endothelial cell line HCMEC/D3 is a useful alternative to primary brain endothelial cells as a model of the blood-brain barrier for studies of central nervous system infection.

Item Type: Journal Article
Copyright Holders: 2009 American Society for Microbiology
ISSN: 1535-9786
Keywords: Cryptococcus neoformans cells; CNS; central nervous system; endothelial cells; blood-brain barrier
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 19390
Depositing User: Users 9108 not found.
Date Deposited: 06 Jan 2010 15:17
Last Modified: 07 Mar 2014 15:06
URI: http://oro.open.ac.uk/id/eprint/19390
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