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Creating context for the use of DNA adduct data in cancer risk assessment: I. Data organization

Jarabek, Annie M.; Pottenger, Lynn H.; Andrews, Larry S.; Casciano, Daniel; Embry, Michelle R.; Kim, James H.; Preston, R. Julian; Reddy, M Vijayaraj; Schoeny, Rita; Shuker, David; Skare, Julie; Swenberg, James; Williams, Gary M. and Zeiger, Errol (2009). Creating context for the use of DNA adduct data in cancer risk assessment: I. Data organization. Critical Reviews in Toxicology, 39(8) pp. 659–678.

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The assessment of human cancer risk from chemical exposure requires the integration of diverse types of data. Such data involve effects at the cell and tissue levels. This report focuses on the specific utility of one type of data, namely DNA adducts. Emphasis is placed on the appreciation that such DNA adduct data cannot be used in isolation in the risk assessment process but must be used in an integrated fashion with other information. As emerging technologies provide even more sensitive quantitative measurements of DNA adducts, integration that establishes links between DNA adducts and accepted outcome measures becomes critical for risk assessment. The present report proposes an organizational approach for the assessment of DNA adduct data (e.g., type of adduct, frequency, persistence, type of repair process) in concert with other relevant data, such as dosimetry, toxicity, mutagenicity, genotoxicity, and tumor incidence, to inform characterization of the mode of action. DNA adducts are considered biomarkers of exposure, whereas gene mutations and chromosomal alterations are often biomarkers of early biological effects and also can be bioindicators of the carcinogenic process.

Item Type: Journal Article
Copyright Holders: 2009 Informa
ISSN: 1547-6898
Keywords: DNA adduct data; cancer risk assessment
Academic Unit/Department: ?? scie-dche ??
Item ID: 19387
Depositing User: Users 9108 not found.
Date Deposited: 06 Jan 2010 15:03
Last Modified: 23 Oct 2012 14:38
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