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Reaction of Naphthoquinones with Substituted Nitromethanes. Facile Synthesis and antifungal activity of Naphtho[2,3-d]isoxazole-4,9-diones

Santos, Maria M.M.; Faria, Natália; Iley, Jim; Coles, Simon J.; Hursthouse, Michael B.; Martins, M. Luz and Moreira, Rui (2010). Reaction of Naphthoquinones with Substituted Nitromethanes. Facile Synthesis and antifungal activity of Naphtho[2,3-d]isoxazole-4,9-diones. Bioorganic and Medicinal Chemistry Letters, 20(1) pp. 193–195.

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DOI (Digital Object Identifier) Link: http://doi.org/10.1016/j.bmcl.2009.10.137
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Abstract

We report here a simple entry into naphtho[2,3-d]isoxazole-4,9-dione system containing a EWG in position 3 using the readily available 2,3-dichloro-1,4-naphthoquinone and nitromethyl derivatives in the presence of base. Antifungal activity of synthesised naphthoquinones was evaluated against ATCC and PYCC reference strains of Candida. The results suggest that the naphtho[2,3-d]isoxazole-4,9-dione scaffold has the potential to be developed into novel and safe therapeutic antifungal agents.

Item Type: Journal Article
Copyright Holders: 2010 Elsevier Ltd
ISSN: 0960-894X
Academic Unit/Department: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 18939
Depositing User: James Iley
Date Deposited: 13 Nov 2009 15:55
Last Modified: 04 Aug 2016 06:55
URI: http://oro.open.ac.uk/id/eprint/18939
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