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Electronic nose responses and acute phase proteins correlate in blood using a bovine respiratory infection

Knobloch, Henri; Schroedl, Wieland; Turner, Claire; Chambers, Mark and Reinhold, Petra (2010). Electronic nose responses and acute phase proteins correlate in blood using a bovine respiratory infection. Sensors and Actuators B: Chemical, 144(1) pp. 81–87.

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DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1016/j.snb.2009.10.034
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Abstract

This study aimed (i) to assess the ability of electronic nose (e-nose) technology to differentiate between blood samples of experimentally infected and non-infected subjects, and (ii) to evaluate e-nose responses given by volatile organic compounds in relation to the acute phase reaction generated in the host. In an animal model of gram-negative bacterial infection (20 calves; intratracheal inoculation of Mannheimia haemolytica A1), the concentrations of the acute phase proteins (APPs; i.e. lipopolysaccharide binding protein and haptoglobin) were measured in serum samples before and after challenge, and headspaces of pre- and post-inoculation serum samples were analysed using a conducting polymer based e-nose. Significant changes of certain e-nose sensor responses allowed discrimination between samples before and after challenge. The maximal changes in responses of sensitive e-nose sensors corresponded to the peak of clinical signs. Significant correlations linked decreasing responses of multiple e-nose sensors to increasing concentrations of APPs in the peripheral blood.

Item Type: Journal Article
Copyright Holders: 2009 Elsevier B.V.
ISSN: 0925-4005
Keywords: electronic nose; acute phase proteins (APP); animal model; gram-negative bacterial infection; Mannheimia haemolytica A1; host response
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Centre for Earth, Planetary, Space and Astronomical Research (CEPSAR)
Biomedical Research Network (BRN)
Item ID: 18891
Depositing User: Claire Turner
Date Deposited: 13 Nov 2009 10:17
Last Modified: 08 Mar 2014 00:48
URI: http://oro.open.ac.uk/id/eprint/18891
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