Epidemiological studies of the non-specific effects of vaccines: II - methodological issues in the design and analysis of cohort studies

Farrington, C. P.; Firth, M. J.; Moulton, L. H.; Ravn, H.; Andersen, P. K. and Evans, S. (2009). Epidemiological studies of the non-specific effects of vaccines: II - methodological issues in the design and analysis of cohort studies. Tropical Medicine and International Health, 14(9) pp. 977–985.

DOI: https://doi.org/10.1111/j.1365-3156.2009.02302.x

Abstract

We review sources of bias which can affect non-randomized cohort studies of non-specific effects of vaccines on child mortality. Using examples from the literature on non-specific effects, we describe different sources of selection and information bias, and, where possible, outline analysis strategies to mitigate or eliminate such biases.

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