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Regenerative capacity of cultured neurons following photodynamic therapy in a 3D collagen gel culture system

Wright, K. E. and Phillips, J. B. (2009). Regenerative capacity of cultured neurons following photodynamic therapy in a 3D collagen gel culture system. In: European Cells and Materials, 18(Sup 2) p. 112.

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Abstract

Photodynamic therapy (PDT) is a promising treatment modality for cancer which involves administration of a photosensitising agent that can be activated subsequently within a patient's cells, resulting in cell death from oxidative damage. Peripheral nerve sparing has been reported following PDT with the photosensitiser meta(tetra-hydroxyphenyl) chlorin (mTHPC) [1 & 2]. Dorsal root ganglia (DRG) neurons have been shown to be relatively insensitive to mTHPC-PDT doses that killed other cell types in a 3D collagen culture system [3]. The aim here was to determine the extent to which 'surviving' neurons were able to sprout neurites as an indication of functional recovery following PDT.

Item Type: Conference Item
Copyright Holders: 2009 Unknown
ISSN: 1473-2262
Project Funding Details:
Funded Project NameProject IDFunding Body
Not SetNot SetOpen University
Extra Information: Poster presentation at Annual meeting of the Tissue and Cell Engineering Society (TCES2009); July 8-10 2009, University of Glasgow, Glasgow, UK; Centre for Cell Engineering (University of Glasgow) and Laboratory for Biomolecular Nanotechnology (University of Strathclyde).
Academic Unit/Department: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Related URLs:
Item ID: 17849
Depositing User: James Phillips
Date Deposited: 15 Dec 2009 13:54
Last Modified: 09 Aug 2016 03:53
URI: http://oro.open.ac.uk/id/eprint/17849
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