Wright, K. E. and Phillips, J. B.
(2009).
Regenerative capacity of cultured neurons following photodynamic therapy in a 3D collagen gel culture system.
European Cells and Materials, 18(Sup 2)
p. 112.
Full text available as:
Abstract
Photodynamic therapy (PDT) is a promising treatment modality for cancer which involves administration of a photosensitising agent that can be activated subsequently within a patient's cells, resulting in cell death from oxidative damage. Peripheral nerve sparing has been reported following PDT with the photosensitiser meta(tetra-hydroxyphenyl) chlorin (mTHPC) [1 & 2]. Dorsal root ganglia (DRG) neurons have been shown to be relatively insensitive to mTHPC-PDT doses that killed other cell types in a 3D collagen culture system [3]. The aim here was to determine the extent to which 'surviving' neurons were able to sprout neurites as an indication of functional recovery following PDT.
| Item Type: |
Journal Article
|
| Copyright Holders: |
2009 Unknown |
| ISSN: |
1473-2262 |
| Funders: |
Open University |
| Extra Information: |
Poster presentation at Annual meeting of the Tissue and Cell Engineering Society (TCES2009); July 8-10 2009, University of Glasgow, Glasgow, UK; Centre for Cell Engineering (University of Glasgow) and Laboratory for Biomolecular Nanotechnology (University of Strathclyde).
|
| Academic Unit/Department: |
Science > Life, Health and Chemical Sciences |
| Related URLs: |
|
| Item ID: |
17849 |
| Depositing User: |
James Phillips
|
| Date Deposited: |
15 Dec 2009 13:54 |
| Last Modified: |
24 Oct 2012 09:45 |
| URI: |
http://oro.open.ac.uk/id/eprint/17849 |
Actions (login may be required)
![[img]](http://oro.open.ac.uk/style/images/fileicons/application_pdf.png)