Astrocyte alignment in 3D collagen gels increases neurite outgrowth; implications for improving spinal cord repair

East, E.; Blum de Oliveira, D.; Golding, J. P. and Phillips, J. B. (2009). Astrocyte alignment in 3D collagen gels increases neurite outgrowth; implications for improving spinal cord repair. In: Tissue and Cell Engineering Society, 8-10th July 2009, Glasgow, p. 13.

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Abstract

A major impediment to tissue engineered repair of CNS damage is the glial scar that forms around implanted graft devices and creates an inhibitory environment for axon growth out of the repair site 1. The glial scar is composed of a 3-dimensional (3D) meshwork of astrocytes which become reactive in response to damage stimuli. Previous studies have shown that longitudinal alignment of astrocytes growing in monolayer is sufficient to direct and enhance the growth of neurites over their surface 2,3. The aim of this work therefore was to develop a 3D culture system in which the effect of astrocyte alignment on neurite growth could be modelled in a spatially relevant environment.

Item Type:

Conference Item

2009 Unknown

ISSN:

1473-2262

External Project Funding Details:

Funded Project Name	Project ID	Funding Body
Not Set	Not Set	The Wellcome Trust

Extra Information:

Oral Abstract presented at Tissue and Cell Engineering Society Annual Conference (TCES2009); July 8-10 2009; University of Glasgow, Glasgow, UK; Centre for Cell Engineering (University of Glasgow) and Laboratory for Biomolecular Nanotechnology (University of Strathclyde).

Academic Unit/Department:

Science > Life, Health and Chemical Sciences
Science

Interdisciplinary Research Centre:

Biomedical Research Network (BRN)

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