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Astrocyte alignment in 3D collagen gels increases neurite outgrowth; implications for improving spinal cord repair

East, E.; Blum de Oliveira, D.; Golding, J. P. and Phillips, J. B. (2009). Astrocyte alignment in 3D collagen gels increases neurite outgrowth; implications for improving spinal cord repair. In: European Cells and Materials, 18(Sup 2) p. 13.

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Abstract

A major impediment to tissue engineered repair of CNS damage is the glial scar that forms around implanted graft devices and creates an inhibitory environment for axon growth out of the repair site 1. The glial scar is composed of a 3-dimensional (3D) meshwork of astrocytes which become reactive in response to damage stimuli. Previous studies have shown that longitudinal alignment of astrocytes growing in monolayer is sufficient to direct and enhance the growth of neurites over their surface 2,3. The aim of this work therefore was to develop a 3D culture system in which the effect of astrocyte alignment on neurite growth could be modelled in a spatially relevant environment.

Item Type: Conference Item
Copyright Holders: 2009 Unknown
ISSN: 1473-2262
Project Funding Details:
Funded Project NameProject IDFunding Body
Not SetNot SetThe Wellcome Trust
Extra Information: Oral Abstract presented at Tissue and Cell Engineering Society Annual Conference (TCES2009); July 8-10 2009; University of Glasgow, Glasgow, UK; Centre for Cell Engineering (University of Glasgow) and Laboratory for Biomolecular Nanotechnology (University of Strathclyde).
Academic Unit/Department: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Related URLs:
Item ID: 17846
Depositing User: James Phillips
Date Deposited: 15 Dec 2009 13:21
Last Modified: 06 Aug 2016 09:24
URI: http://oro.open.ac.uk/id/eprint/17846
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