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Monitoring vaccine safety using case series cumulative sum charts

Musonda, Patrick; Hocine, Mounia N.; Andrews, Nick J.; Tubert-Bitter, Pascale and Farrington, Paddy C. (2008). Monitoring vaccine safety using case series cumulative sum charts. Vaccine, 26(42) pp. 5358–5367.

DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1016/j.vaccine.2008.08.010
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Abstract

We adapt the self-controlled case series method for routine surveillance of vaccine safety using cumulative sum (CUSUM) charts. The CUSUM surveillance method we propose is applicable for detecting associations that arise in a short pre-determined risk period following vaccination. The performance of the case series CUSUM is investigated through simulations. We illustrate the method using retrospective analyses of influenza vaccine and Bell's palsy, and MMR vaccine and febrile convulsions.

Item Type: Journal Article
Copyright Holders: 2008 Elsevier Ltd.
ISSN: 0264-410X
Project Funding Details:
Funded Project NameProject IDFunding Body
Not SetNot SetMRC
Not SetNot SetEPSRC
Not SetNot SetFondation pour la Recherche Médicale
Keywords: adverse event; self-controlled case series method; CUSUM; average run length; surveillance; vaccine
Academic Unit/Department: Mathematics, Computing and Technology > Mathematics and Statistics
Item ID: 15751
Depositing User: Colin Smith
Date Deposited: 14 Apr 2009 20:02
Last Modified: 20 Mar 2014 14:51
URI: http://oro.open.ac.uk/id/eprint/15751
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