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Hepatitis B vaccination and first central nervous system demyelinating events: Reanalysis of a case-control study using the self-controlled case series method

Hocine, M. N.; Farrington, C. P.; Touze, E.; Whitaker, H. J.; Fourrier, A.; Moreau, T. and Tubert-Bitter, P. (2007). Hepatitis B vaccination and first central nervous system demyelinating events: Reanalysis of a case-control study using the self-controlled case series method. Vaccine, 25(31) pp. 5938–5943.

DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1016/j.vaccine.2007.05.032
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Abstract

The hypothesis that hepatitis B vaccination is a risk factor for multiple sclerosis has been discussed at length. The data from an earlier case-control study were reanalyzed using the self-controlled case series method. Using the matched cases from the case-control study, we found a relative incidence of 1.68, 95% CI (0.77-3.68) for the 0-60-day post-vaccination risk period; this compares to an odds ratio of 1.8, 95% CI (0.7-4.6). When an additional 53 unmatched cases not used in the case-control study were included, the relative incidence was 1.35, 95% CI (0.66-2.79). Our results throw further light on the methodological aspects of the case series method. We recommend that, when case-control studies of vaccination and adverse events are planned, case series analyses based on the cases are also undertaken when appropriate. (c) 2007 Elsevier Ltd. All rights reserved.

Item Type: Journal Article
ISSN: 0264-410X
Academic Unit/Department: Mathematics, Computing and Technology > Mathematics and Statistics
Item ID: 15613
Depositing User: Colin Smith
Date Deposited: 24 Apr 2009 08:45
Last Modified: 02 Dec 2010 20:26
URI: http://oro.open.ac.uk/id/eprint/15613
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