Tai, Leon M.; Loughlin, A. Jane; Male, David K. and Romero, Ignacio A.
|DOI (Digital Object Identifier) Link:||http://dx.doi.org/10.1038/jcbfm.2009.42|
|Google Scholar:||Look up in Google Scholar|
The clearance of amyloid beta (Aβ) from the brain represents a novel therapeutic target for Alzheimer’s disease. Conflicting data exists as to the contribution of ATP binding cassette transporters to the clearance of Aβ through the blood-brain barrier. We therefore investigated whether Aβ could be a substrate for P-glycoprotein (P-gp) and/or breast cancer resistance protein (BCRP) using a human brain endothelial cell line, hCMEC/D3. P-gp and BCRP inhibition increased apical-to-basolateral, but not basolateral-to-apical, permeability of hCMEC/D3 cells to 125I Aβ 1-40. Our in vitro data suggest that P-gp and BCRP might act to prevent blood-borne Aβ 1-40 entering the brain.
|Item Type:||Journal Article|
|Copyright Holders:||2009 ISCBFM|
|Keywords:||Alzheimer’s disease; amyloid beta; BCRP; blood–brain barrier; P-gp|
|Academic Unit/Department:||Science > Life, Health and Chemical Sciences|
|Interdisciplinary Research Centre:||Biomedical Research Network (BRN)
Innovation, Knowledge & Development research centre (IKD)
|Depositing User:||Astrid Peterkin|
|Date Deposited:||17 Apr 2009 09:16|
|Last Modified:||07 Mar 2014 13:39|
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