Dopamine- and tyramine-based derivatives of triazenes. Activation by tyrosinase and implications for prodrug design

Perry, M. J.; Mendes, E.; Simplício, A. L.; Coelho, A.; Iley, J.; Moreira, R. and Francisco, A. P. (2009). Dopamine- and tyramine-based derivatives of triazenes. Activation by tyrosinase and implications for prodrug design. European Journal of Medicinal Chemistry, 44(8) pp. 3228–3234.

DOI: https://doi.org/10.1016/j.ejmech.2009.03.025

Abstract

We report the synthesis of triazene derivatives, and their evaluation as substrates for tyrosinase. The conversion of prodrugs to the ortho-quinone was confirmed by LC-MS.

Viewing alternatives

Metrics

Item Actions

Export

You can export this page using these formats Digital Object Identifier - DOI

About

• Item ORO ID
• 15415
• Item Type
• Journal Item
• ISSN
• 0223-5234
• Academic Unit or School
• Other Departments > Business Development Unit
  Other Departments
• Copyright Holders
• © 2009 Elsevier Masson SAS
• Depositing User
• James Iley