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Dopamine- and tyramine-based derivatives of triazenes. Activation by tyrosinase and implications for prodrug design

Perry, M. J.; Mendes, E.; Simplício, A. L.; Coelho, A.; Iley, J.; Moreira, R. and Francisco, A. P. (2009). Dopamine- and tyramine-based derivatives of triazenes. Activation by tyrosinase and implications for prodrug design. European Journal of Medicinal Chemistry, 44(8) pp. 3228–3234.

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DOI (Digital Object Identifier) Link: http://doi.org/10.1016/j.ejmech.2009.03.025
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Abstract

We report the synthesis of triazene derivatives, and their evaluation as substrates for tyrosinase. The conversion of prodrugs to the ortho-quinone was confirmed by LC-MS.

Item Type: Journal Article
Copyright Holders: 2009 Elsevier Masson SAS
ISSN: 0223-5234
Academic Unit/Department: Science
Item ID: 15415
Depositing User: James Iley
Date Deposited: 24 Apr 2009 09:39
Last Modified: 23 Feb 2016 21:08
URI: http://oro.open.ac.uk/id/eprint/15415
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