Khan, Huma and Missailidis, Sotiris
(2008).
![[img]](http://oro.open.ac.uk/style/images/fileicons/application_pdf.png)
|
PDF
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Download (870kB) |
| URL: | http://issuu.com/gtmb/docs/vol12a |
|---|---|
| Google Scholar: | Look up in Google Scholar |
Abstract
Nucleic acid sequences can produce a wide variety of three-dimensional conformations. Some of these structural forms are able to interact with proteins and small molecules with high affinity and specificity. These sequences, comprising either double or single stranded oligonucleotides, are called 'aptamers' based on the Greek word aptus, which means 'to fit'. Using an efficient selection process, randomised oligonucleotide libraries can be rapidly screened for aptamers with the appropriate binding characteristics. This technology has spawned the development of a new class of oligonucleotide therapeutic products. However, while interest among pharmaceutical companies continues to grow with some candidates already in clinical trials and one in the market, there appears to be some reluctance to fully explore the diagnostic potential of this technology. This article will review aptamer developments in diagnostics, compare them with other oligonucleotide therapeutics and highlight both potentials and pitfalls of technological development in this area.
| Item Type: | Journal Item |
|---|---|
| Copyright Holders: | 2008 Gene Therapy and Molecular Biology |
| ISSN: | 1529-9120 |
| Keywords: | aptamers; diagnostics; oncology; aptazymes; aptasensors |
| Academic Unit/School: | Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences Faculty of Science, Technology, Engineering and Mathematics (STEM) |
| Item ID: | 15255 |
| Depositing User: | Sotiris Missailidis |
| Date Deposited: | 26 Jan 2011 16:27 |
| Last Modified: | 13 Jan 2018 18:11 |
| URI: | http://oro.open.ac.uk/id/eprint/15255 |
| Share this page: |     |
Download history for this item
These details should be considered as only a guide to the number of downloads performed manually. Algorithmic methods have been applied in an attempt to remove automated downloads from the displayed statistics but no guarantee can be made as to the accuracy of the figures.
CORE (COnnecting REpositories)
CORE (COnnecting REpositories)