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How to improve post genomic knowledge discovery using imputation

Sehgal, Shoaib M.; Gondal, Iqbal; Dooley, Laurence S. and Coppel, Ross (2009). How to improve post genomic knowledge discovery using imputation. EURASIP Journal on Bioinformatics and Systems Biology, 2009(717136) pp. 1–14.

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URL: http://www.hindawi.com/GetArticle.aspx?doi=10.1155...
DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1155/2009/717136
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Abstract

While microarrays make it feasible to rapidly investigate many complex biological problems, their multistep fabrication has the proclivity for error at every stage. The standard tactic has been to either ignore or regard erroneous gene readings as missing values, though this assumption can exert a major influence upon postgenomic knowledge discovery methods like gene selection and gene regulatory network (GRN) reconstruction. This has been the catalyst for a raft of new flexible imputation algorithms including local least square impute and the recent heuristic collateral missing value imputation, which exploit the biological transactional behaviour of functionally correlated genes to afford accurate missing value estimation. This paper examines the influence of missing value imputation techniques upon postgenomic knowledge inference methods with results for various algorithms consistently corroborating that instead of ignoring missing values, recycling microarray data by flexible and robust imputation can provide substantial performance benefits for subsequent downstream procedures.

Item Type: Journal Article
ISSN: 1687-4145
Academic Unit/Department: Mathematics, Computing and Technology > Computing & Communications
Interdisciplinary Research Centre: Centre for Research in Computing (CRC)
Item ID: 14984
Depositing User: Laurence Dooley
Date Deposited: 23 Feb 2009 14:42
Last Modified: 25 Oct 2012 10:25
URI: http://oro.open.ac.uk/id/eprint/14984
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