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Case series analysis for censored, perturbed, or curtailed post-event exposures

Farrington, Paddy; Whitaker, Heather J. and Hocine, Mounia N. (2009). Case series analysis for censored, perturbed, or curtailed post-event exposures. Biostatistics, 10(1) pp. 3–16.

DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1093/biostatistics/kxn013
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Abstract

A new method is developed for analyzing case series data in situations where occurrence of the event censors, curtails, or otherwise affects post-event exposures. Unbiased estimating equations derived from the self-controlled case series model are adapted to allow for exposures whose occurrence or observation is influenced by the event. The method applies to transient point exposures and rare nonrecurrent events. Asymptotic efficiency is studied in some special cases. A computational scheme based on a pseudo-likelihood is proposed to make the computations feasible in complex models. Simulations, a validation study, and 2 applications are described.

Item Type: Journal Article
ISSN: 1468-4357
Academic Unit/Department: Mathematics, Computing and Technology > Mathematics and Statistics
Item ID: 12897
Depositing User: Paddy Farrington
Date Deposited: 19 Jan 2009 06:47
Last Modified: 03 Dec 2012 12:09
URI: http://oro.open.ac.uk/id/eprint/12897
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