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Inhibiting effect of D1, but not D2 antagonist administered to the striatum on retention of passive avoidance in the chick

Kabai, Peter; Stewart, Michael G.; Tarcali, József and Csillag, András (2004). Inhibiting effect of D1, but not D2 antagonist administered to the striatum on retention of passive avoidance in the chick. Neurobiology of Learning and Memory, 81(2) pp. 155–158.

DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1016/j.nlm.2003.12.002
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Abstract

The avian lobus parolfactorius, equivalent to the medial striatum (caudate-putamen) of mammals, has been shown to be of crucial importance in passive avoidance training in day-old domestic chicks, where the aversive stimulus is the bitter tasting substance methylanthranilate. Here we report that the specific D1 antagonist SCH23390, injected into the lobus parolfactorius of day-old chicks (Gallus domesticus) prior to training, impaired performance on testing 30 min post-training at low doses (0.5 and 25 nmol). Sulpiride, a D2 antagonist, had no significant effect on performance in comparable doses. The early D1 activation may signify an essential mechanism leading to storage itself or to the canalisation of the relevant association to a permanent store.

Item Type: Journal Article
ISSN: 1074-7427
Keywords: Bird; Domestic chick; Striatum; Dopamine; Avoidance training; Taste aversion; Avian brain; Memory; Learning;
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 12768
Depositing User: Astrid Peterkin
Date Deposited: 02 Jan 2009 02:01
Last Modified: 07 Mar 2014 15:05
URI: http://oro.open.ac.uk/id/eprint/12768
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