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How will public and animal health interventions drive life-history evolution in parasitic nematodes?

Lynch, Penelope A.; Grimm, Uwe and Read, Andrew F. (2008). How will public and animal health interventions drive life-history evolution in parasitic nematodes? Parasitology, 135(13) pp. 1599–1611.

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DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1017/S0031182008000309
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Abstract

Infection caused by parasitic nematodes of humans and livestock can have significant health and economic costs. Treatments aimed at alleviating these costs, such as chemotherapy and vaccination, alter parasite survival and reproduction, the main selective pressures shaping life-history traits such as age to maturity, size and fecundity. Most authors have argued that the life-history evolution prompted by animal and public health programmes would be clinically beneficial, generating smaller, less fecund worms, and several mathematical models support this view. However, using mathematical models of long-lasting interventions, such as vaccination, and regularly repeated short interventions, such as drenching, we show here that the expected outcome actually depends on how mortality rates vary as a function of worm size and developmental status. Interventions which change mortality functions can exert selection pressure to either shorten or extend the time to maturity, and thus increase or decrease worm fecundity and size. The evolutionary trajectory depends critically on the details of the mortality functions with and without the intervention. Earlier optimism that health interventions would always prompt the evolution of smaller, less fecund and hence clinically less damaging worms is premature.

Item Type: Journal Article
Copyright Holders: 2008 Cambridge University Press
ISSN: 0031-1820
Keywords: mortality rates; health interventions; maturation time; vaccination; chemotherapy; anthelminthics
Academic Unit/Department: Mathematics, Computing and Technology > Mathematics and Statistics
Item ID: 12312
Depositing User: Uwe Grimm
Date Deposited: 14 Nov 2008 11:05
Last Modified: 26 Oct 2012 13:44
URI: http://oro.open.ac.uk/id/eprint/12312
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