The Open UniversitySkip to content
 

Differences in sensitivity to mTHPC-mediated photodynamic therapy of neurons, glial cells and MCF7 cells in a 3-dimensional cell culture model

Wright, K. E.; MacRobert, A. J. and Phillips, J. B. (2008). Differences in sensitivity to mTHPC-mediated photodynamic therapy of neurons, glial cells and MCF7 cells in a 3-dimensional cell culture model. In: Photodynamic Therapy and Photodiagnosis in Clinical Practice, 7- 11 October 2008, Brixen, Italy.

Full text available as:
[img]
Preview
PDF (Not Set) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Download (41Kb)
URL: http://www.bio.unipd.it/PDT2008/pagine/Final_PDT20...
Google Scholar: Look up in Google Scholar

Abstract

The effect of photodynamic therapy (PDT) on the cells of the nervous system is an important consideration in the treatment of tumours that are located within or adjacent to the brain, spinal cord and peripheral nerves. Previous studies have reported the sparing of nerves during PDT using meta-tetrahydroxyphenylchlorin (mTHPC, Foscan®) in patients and in animal models. The aim of this study was to investigate the effects of mTHPC on key nervous system cells using a 3-dimensional cell culture system for the accurate detection of differences in sensitivity.

Item Type: Conference Item
Keywords: mTHPC; neurons; satellite glia; MCF-7; astrocytes; photodynamic therapy;
Academic Unit/Department: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 12027
Depositing User: James Phillips
Date Deposited: 22 Oct 2008 10:28
Last Modified: 05 Aug 2016 17:08
URI: http://oro.open.ac.uk/id/eprint/12027
Share this page:

Download history for this item

These details should be considered as only a guide to the number of downloads performed manually. Algorithmic methods have been applied in an attempt to remove automated downloads from the displayed statistics but no guarantee can be made as to the accuracy of the figures.

▼ Automated document suggestions from open access sources

Actions (login may be required)

Policies | Disclaimer

© The Open University   + 44 (0)870 333 4340   general-enquiries@open.ac.uk